Volume 112, Issue 9, Pages (May 2017)

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Volume 112, Issue 9, Pages 1767-1772 (May 2017) Microvessel Chaste: An Open Library for Spatial Modeling of Vascularized Tissues James A. Grogan, Anthony J. Connor, Bostjan Markelc, Ruth J. Muschel, Philip K. Maini, Helen M. Byrne, Joe M. Pitt-Francis Biophysical Journal Volume 112, Issue 9, Pages 1767-1772 (May 2017) DOI: 10.1016/j.bpj.2017.03.036 Copyright © 2017 Biophysical Society Terms and Conditions

Figure 1 Given here is a schematic showing the components used in the Microvessel Chaste library, and how they can be used to generate custom simulation software. Shaded components are not currently used in the library. To see this figure in color, go online. Biophysical Journal 2017 112, 1767-1772DOI: (10.1016/j.bpj.2017.03.036) Copyright © 2017 Biophysical Society Terms and Conditions

Figure 2 (a) A 3D intravital image of a tumor microvessel network (red) is obtained and a skeleton extracted as described in Grogan et al. (22). A cylindrical region of interest with diameter 1.2 mm is extracted for the example simulation. (b) A tumor growth simulation using the extracted microvessel network and Microvessel Chaste is given. The predicted evolution of the tumor over 25 h is shown, including blood pressure in growing vessels, VEGF concentrations in the extravascular space, and discrete cells. To see this figure in color, go online. Biophysical Journal 2017 112, 1767-1772DOI: (10.1016/j.bpj.2017.03.036) Copyright © 2017 Biophysical Society Terms and Conditions

Figure 3 (a) Given here are images from a cornea micropocket experiment showing microvessels (dark red) at 3–5 days postpellet implantation (26). (b) Shown here is application of the Microvessel Chaste library in modeling a similar experiment. To see this figure in color, go online. Biophysical Journal 2017 112, 1767-1772DOI: (10.1016/j.bpj.2017.03.036) Copyright © 2017 Biophysical Society Terms and Conditions