Centrosomes: PIDDosome Joins the Counting Game Susana Godinho  Current Biology  Volume 27, Issue 6, Pages R237-R239 (March 2017) DOI: 10.1016/j.cub.2017.02.001 Copyright © 2017 Terms and Conditions

Figure 1 Centrosome amplification induces p53 stabilisation through PIDDosome activation. Increased numbers of centrosomes lead to caspase-2 activation via the PIDDosome. Caspase-2 is an endopeptidase, which, when activated, cleaves the p53 inhibitor MDM2, promoting p53 stabilisation. Stabilised p53 can translocate to the nucleus where it activates the transcription of several genes, including the cell-cycle inhibitor p21, thus causing cell-cycle arrest. Current Biology 2017 27, R237-R239DOI: (10.1016/j.cub.2017.02.001) Copyright © 2017 Terms and Conditions