Multigenerational cohorts in patients with asthma and allergy

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Presentation transcript:

Multigenerational cohorts in patients with asthma and allergy S. Hasan Arshad, DM, Wilfried Karmaus, Drmed, Hongmei Zhang, PhD, John W. Holloway, PhD Journal of Allergy and Clinical Immunology Volume 139, Issue 2, Pages 415-421 (February 2017) DOI: 10.1016/j.jaci.2016.12.002 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Three generations of the Isle of Wight birth cohort. The birth cohort participants were recruited in 1989-1990 and have been assessed at 1, 2, 4, 10, 18, and 27 years. Data and samples were collected from the parents of the cohort in 1989-1990. The third generation (children of the original birth cohort) have been recruited since 2010 and to date assessed at 3, 12, 24, 36, and 60 months. Journal of Allergy and Clinical Immunology 2017 139, 415-421DOI: (10.1016/j.jaci.2016.12.002) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Vertical and induced epigenetic transmission models. A, The vertical epigenetic transmission model proposes direct transfer of epigenetic information from parent to child in successive generations. B, The alternative model, induced epigenetic transmission, proposes that maternal disease is an essential element in the chain of epigenetic transmission of information. Journal of Allergy and Clinical Immunology 2017 139, 415-421DOI: (10.1016/j.jaci.2016.12.002) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions