Effect of aging on sputum inflammation and asthma control

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Presentation transcript:

Effect of aging on sputum inflammation and asthma control Paula J. Busse, MD, Janette M. Birmingham, MS, Agustin Calatroni, MA, MS, Joseph Manzi, BA, Anna Goryachokovsky, BA, Giselle Fontela, BS, Alex D. Federman, MD, MPH, Juan P. Wisnivesky, MD, DrPH Journal of Allergy and Clinical Immunology Volume 139, Issue 6, Pages 1808-1818.e6 (June 2017) DOI: 10.1016/j.jaci.2016.09.015 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Aged patients with asthma have increased sputum neutrophil and eosinophil values. A, Total cell numbers per milliliter of sputum for neutrophils, eosinophils, macrophages, and total cells. B, Percentages of neutrophils, eosinophils, macrophages, and lymphocytes. The box plot represents medians (midline), interquartile ranges (shaded boxes), and ranges (whiskers). Groups not sharing the same letter (a or b) are significantly different (P < .05). Journal of Allergy and Clinical Immunology 2017 139, 1808-1818.e6DOI: (10.1016/j.jaci.2016.09.015) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Association between sputum inflammation and asthma control and hospitalizations according to age group. Asthmatic patients were classified based on sputum cellular percentages and cytokine expression into high or low groups to evaluate the association between ACT scores (A) and ORs (B) for asthma hospitalization in the previous 12 months. Interaction is significant at a P value of less than .05. Journal of Allergy and Clinical Immunology 2017 139, 1808-1818.e6DOI: (10.1016/j.jaci.2016.09.015) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 IL-4 expression in induced sputum of asthmatic patients versus healthy control subjects. The dot plot demonstrates numbers of samples greater than and less than the level of detection (dashed line). Younger subjects are denoted by solid circles, and aged subjects are denoted by open squares. Journal of Allergy and Clinical Immunology 2017 139, 1808-1818.e6DOI: (10.1016/j.jaci.2016.09.015) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 A, Flow cytometric gating strategy of sputum Treg cells: 1, CD3+ gate; 2, CD3+CD4+ gate; and 3, CD3+CD4+Foxp3+CD127low gate with isotype controls. SSC, Side scatter. B, Percentages of sputum Treg cells in aged and younger patients with asthma and healthy age-matched control subjects. Treg cells are reported as the percentage of CD3+CD4+ cells expressing Foxp3+CD127low. Data are presented in medians (interquartile ranges) and compared by using Wilcoxon analysis. Journal of Allergy and Clinical Immunology 2017 139, 1808-1818.e6DOI: (10.1016/j.jaci.2016.09.015) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions