The Missing Antibody: The Pitfalls of ANCA Testing

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Presentation transcript:

The Missing Antibody: The Pitfalls of ANCA Testing James Wingfield Digby, MD, MRCP, DTMH, Brendan Tinwell, MD, FRCPath, Joanna Sheldon, PhD, FRCPath, Joe Wang, MD, MRCP, PhD The American Journal of Medicine Volume 130, Issue 3, Pages e93-e96 (March 2017) DOI: 10.1016/j.amjmed.2016.11.003 Copyright © 2016 Terms and Conditions

Figure 1 Chest computed tomography showing extensive bilateral patchy air space infiltrates and ground-glass changes. The American Journal of Medicine 2017 130, e93-e96DOI: (10.1016/j.amjmed.2016.11.003) Copyright © 2016 Terms and Conditions

Figure 2 Video-assisted thoracoscopic lung biopsy (A) low-power (40×) view of lung demonstrating focal organizing pneumonia (arrow) and subtle perivascular inflammation (insert 200×) (hematoxylin & eosin stain). (B) High-power (200×) view showing coarse haemosiderin deposition within alveolar macrophages (solid arrow) and fine deposition within alveolar septa and the wall of a small blood vessel (open arrow – pulmonary hemosiderosis) (Perls stain). The American Journal of Medicine 2017 130, e93-e96DOI: (10.1016/j.amjmed.2016.11.003) Copyright © 2016 Terms and Conditions

Figure 3 Renal biopsy showing evidence of acute necrotizing crescentic glomerulopathy (arrow) with a relatively well-preserved background interstitium (hematoxylin & eosin stain, 200×). The American Journal of Medicine 2017 130, e93-e96DOI: (10.1016/j.amjmed.2016.11.003) Copyright © 2016 Terms and Conditions