Effects of doxorubicin and epirubicin on proliferation and apoptosis in the hyperplastic livers of transgenic zebrafish larvae. Effects of doxorubicin.

Slides:

Advertisements

Similar presentations

Mitochondria localize to both the front and the rear of neutrophils.

Advertisements

Fig. 3. BET inhibition reduces homologous recombination.

Visualisation of metabolic tissues in zebrafish.

UCN‐01 inhibits human IPF lung fibroblast pathological phenotypes and attenuates lung fibrosis induced by bleomycin injury UCN‐01 inhibits human IPF lung.

Fig. 1. Representative images of the four cell lines using fluorescence microscopy. Representative images of the four cell lines using fluorescence microscopy.

Fig. 4. Seeding density modulates cell shape in both cell types

Fig. 2. abu/pqn genes are expressed in the pharyngeal cuticle

A subset of Trp53CKO fiber cells fail to exit the cell cycle, but express fiber-cell-specific markers. A subset of Trp53CKO fiber cells fail to exit the.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Effect of OLHHA on the protein expression of relevant enzymes and factors related to lipid metabolism in the liver of obese Zucker rats. Effect of OLHHA.

Fig. 1. Mitochondrial internalization in cardiomyocytes.

Concentration of biomarkers of haemostasis.

Neutralization and knockdown of TGFβ2 results in fewer nephrons ex vivo. Neutralization and knockdown of TGFβ2 results in fewer nephrons ex vivo. (A,B)

Fig. 3. Inactivation of the Wnt/β-catenin signaling pathway inhibited cell proliferation and induced apoptosis in A549 and SPC-A-1 cells. Inactivation.

Indirect fluorescence assay of N. gruberi cells.

Hipk induces cell spreading.

Fig. 2. Salivary glands from RasV12-expressing larvae produce MMP1, release tissue fragments into the hemolymph and express apoptotic markers.Salivary.

Survival and telomere length of G2tert−/− zebrafish in a p53−/− background. Survival and telomere length of G2tert−/− zebrafish in a p53−/− background.

Patient and control ONS cells had very large differences in gene expression. Patient and control ONS cells had very large differences in gene expression.

Challenge with oxazolone results in epithelial hyperplasia and influx of inflammatory cells into the epidermis and dermis and keratosis as observed in.

Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice. Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice.

The initial targeting of Sec61b mRNA to the ER is partially dependent on ribosomes and translation. The initial targeting of Sec61b mRNA to the ER is partially.

Formation of papilloma lesions in the UroIICre+Fgfr3+/K644EK-RasG12D/+ model. Formation of papilloma lesions in theUroIICre+Fgfr3+/K644EK-RasG12D/+model.

Fgfr3 mutation is not the sole driver of tumorigenesis in the bladder.

Doxorubicin viability in the presence and absence of Herceptin

P53 is responsible for the induction of apoptosis, developmental malformations and mortality of G1 and G2tert mutant zebrafish. p53 is responsible for.

Increased osteoclastogenesis in the mandibular bone of Fgfr2+/S252W embryos at E16.5. Increased osteoclastogenesis in the mandibular bone of Fgfr2+/S252W.

Fig. 7. ML mediated suppression of SAHA-induced up-regulation of tRNA as a potential mechanism that contributes to the enhanced anti-cancer actions.

Transduction with Cre-expressing adenoviruses induces cardiomyocyte apoptosis and shows that transgene insertion is not required. Transduction with Cre-expressing.

Inflammation precedes pigment cell migration to a wound.

Detection of nuclear foci by FISH on frozen sections of diaphragm muscle prepared from 2-month-old DMSXL mice. Detection of nuclear foci by FISH on frozen.

Overexpression of individual signaling pathway components does not phenocopy the cell-spreading phenotype induced by elevated Hipk. Overexpression of individual.

The effect of TDP-43A315T expression on dendrite spine development.

Comparison ofMyc-induced zebrafish liver tumors with different stages of human HCC and seven mouse HCC models. Comparison ofMyc-induced zebrafish liver.

An inhibitor of HSP90β reduces the level of HNF4A protein in hepatic progenitor cells. An inhibitor of HSP90β reduces the level of HNF4A protein in hepatic.

Chemical chaperone 4-PBA rescues the hi559 GI phenotype.

Loss of LAR phosphatase activity is associated with decreased adhesion complex formation. Loss of LAR phosphatase activity is associated with decreased.

Characterization of zebrafish muscle wasting in krasG12V-induced HCC zebrafish. 4-month-old male adult krasG12V and WT zebrafish were treated with dox.

The effect of TDP-43A315T expression at the synapse.

Cellular reaction to intraventricular DMSO injection.

Chronic phenytoin increases activity levels in Mecp2Null/Y mice.

Rgs16::GFP expression in pancreatic neoplasia.

Effect of the plastid translation inhibitor Spec on LR development

TOR, but not OSP, blocks STx2B transport and alters endosomal dynamics

Fig. 1. PARN is differentially expressed in breast cancer versus non-cancerous tissue/cells. PARN is differentially expressed in breast cancer versus non-cancerous.

Tumor location determines response to intravenous FOLFIRINOX chemotherapy. Tumor location determines response to intravenous FOLFIRINOX chemotherapy. (A)

Effect of Dipy on the expression of chondrogenic markers.

Effect of γ-secretase inhibition on the vulnerability of primary neurons to OGD. (A) Experimental design. Effect of γ-secretase inhibition on the vulnerability.

HEK-cFXN cells show a correlation among ROS levels, LIP and frataxin expression. HEK-cFXN cells show a correlation among ROS levels, LIP and frataxin expression.

ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. (A,B)

SW fraction induces S phase arrest and apoptosis.

KIF13A depletion leads to a drop in virus titers, without affecting viral protein expression. KIF13A depletion leadsto a drop in virus titers, without.

The zebrafish swdp75fm and swdp82mf mutations cause exocrine pancreatic hypoplasia and reduced skin pigmentation. The zebrafish swdp75fm and swdp82mf mutations.

Overexpression of cyp7a1 in the liver ameliorates tumor-induced liver inflammation. Overexpression of cyp7a1 in the liver ameliorates tumor-induced liver.

HFHC/STZ guinea pigs develop insulin-independent diabetes that is responsive to oral antihyperglycemic therapy. HFHC/STZ guinea pigs develop insulin-independent.

Peroxisome speeds were slower in patient and control cells.

Small molecule suppression of ATXN3-CAG89 aggregation.

The absence of host Fbln5 results in increased apoptosis and decreased proliferation in Pan02 tumors. The absence of host Fbln5 results in increased apoptosis.

Effects of paclitaxel and vinblastine.

Generation of a genetic model of chronic β-cell inflammation in zebrafish. Generation of a genetic model of chronic β-cell inflammation in zebrafish. (A)

Aplf downregulation does not induce cellular arrest.

BMOL3 LPCs can differentiate towards the hepatocyte lineage.

Decreased enzymatic activity in PKG mutants increases time to recovery from an electroshock. Decreased enzymatic activity in PKG mutants increases time.

Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol disrupts the mitotic spindle and prevents mitotic exit inDrosophila.

2DG suppresses of lamellipodia and filopodia and causes disorganization of F-actin filaments in murine endothelial cells. 2DG suppresses of lamellipodia.

Tsg protein stimulates endothelial cell migration, proliferation and collagen gel spheroid sprouting. Tsg protein stimulates endothelial cell migration,

Regulation of Bcl-2 family proteins in the hypothalamus of non-diabetic and diabetic IRS2−/− mice. Regulation of Bcl-2 family proteins in the hypothalamus.

Upon challenge with oxazolone, human leukocytes (mainly consisting of T cells) infiltrate the dermis and epidermis. Upon challenge with oxazolone, human.

Induction of apoptosis by NS398.

Quantification of TUNEL staining and OS length among the rab11a constructs. Quantification of TUNEL staining and OS length among the rab11a constructs.

Presentation transcript:

Effects of doxorubicin and epirubicin on proliferation and apoptosis in the hyperplastic livers of transgenic zebrafish larvae. Effects of doxorubicin and epirubicin on proliferation and apoptosis in the hyperplastic livers of transgenic zebrafish larvae. (A) An example of the whole liver after dissection in both bright-field and fluorescent images. Scale bars: 50 μm. (B) Representative images of BrdU and TUNEL staining in the DMSO-, doxorubicin- and epirubicin-treated zebrafish liver with EGFP-krasG12V over-expression. Scale bars: 10 μm. (C) Statistics of the DMSO-, doxorubicin- and epirubicin-treated liver size from the transgenic larvae (n=16). The values are means±s.e.m., with statistical differences being determined by one-way ANOVA, ***P<0.001; NS, not significant. (D) Statistics of BrdU and TUNEL labelling in the DMSO-, doxorubicin- and epirubicin-treated zebrafish liver with EGFP-krasG12V over-expression (n=16). The values are means±s.e.m., with statistical differences being determined by one-way ANOVA; *P<0.05, ***P<0.001; NS, not significant. (E) The cytotoxicity of doxorubicin and epirubicin in the liver cancer cells BEL7402 and Huh7 using the MTT assay. The dashed lines are the IC50 values for each compound. (F) The statistical results of the IC50 of doxorubicin and epirubicin in the liver cancer cells BEL7402 and Huh7. The values are means±s.e.m., with statistical differences being determined by Student's t-test; *P<0.05, ***P<0.001. Yuxiao Yao et al. Dis. Model. Mech. 2017;10:1155-1164 © 2017. Published by The Company of Biologists Ltd