Non-Mendelian genetics

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Presentation transcript:

Non-Mendelian genetics Gil McVean, Department of Statistics, Oxford

Genomic imprinting Parent-of-origin specific expression Mammals, plants, insects

Paramutation Inherited interactions between homologous alleles ‘Weak’ alleles convert ‘Strong’ alleles

Maternal effects Maternally derived products in embryos Leads to death of non-carrier offspring

Phenotypic buffering HSP90 chaperone can ‘mask’ the deleterious effects of mutation Block HSP90 > mutations ‘exposed’ Select for mutations Exposed phenotype stable even with HSP90 Rutherford & Lindquist (1998)

Mechanisms of epigenetics Methylation Chromatin remodelling Histone modification RNA interference/interactions

Epigenetics and evolution What selection pressures led to the origin of epigenetic systems? Are epigenetically inherited characters important in evolution?