Chapter 33 Interaction of Genetic Factors With Nutrition in Cancer Copyright © 2016 Elsevier Inc. All rights reserved.

Copyright © 2016 Elsevier Inc. All rights reserved. FIGURE 33.1: The effect of a dietary factor or other nutritional exposure on the rate of cancer might vary depending on the presence of a particular genetic factor. Adapted from V. Andersen, R. Holst, U. Vogel, Systematic review: diet-gene interactions and the risk of colorectal cancer, Aliment. Pharmacol. Ther. 37 (4) (2013) 383391. Copyright © 2016 Elsevier Inc. All rights reserved.

Copyright © 2016 Elsevier Inc. All rights reserved. FIGURE 33.2: Genome-wide association studies. Copyright © 2016 Elsevier Inc. All rights reserved.

Copyright © 2016 Elsevier Inc. All rights reserved. FIGURE 33.3: Bioactive food components may interact with genes and their products in a number of different ways, including interactions with the coding DNA, with other parts of the chromosome structure, with the messenger RNA, and with the protein product after translation. From J.A. Milner, Molecular targets for bioactive food components, J. Nutr. 134 (2004) 2492S2498S. Copyright The American Society of Nutrition. Reprinted by permission. Copyright © 2016 Elsevier Inc. All rights reserved.

Copyright © 2016 Elsevier Inc. All rights reserved. FIGURE 33.4: Diet and gene interactions. Copyright © 2016 Elsevier Inc. All rights reserved.

Copyright © 2016 Elsevier Inc. All rights reserved. FIGURE 33.5: Interrelationship between the biotransformation enzyme systems. From R.E. Patterson, D.L. Eaton, J.D. Potter, The genetic revolution: change and challenge for the dietetics profession, J. Am. Diet. Assoc. 99 (1999) 14121420. Copyright The American Dietetic Association. Reprinted by permission. Copyright © 2016 Elsevier Inc. All rights reserved.

Copyright © 2016 Elsevier Inc. All rights reserved. FIGURE 33.6: GWAS of SNP with blood concentrations of the vitamin D binding protein. For each SNP location on the chromosome (x-axis) there is a p-value for the association (y-axis). There were two SNPs, both in the binding protein (chromosome 4) that were strongly associated with the blood concentration of the binding protein. From K.A. Moy, A.M. Mondul, H. Zhang, S.J. Weinstein, W. Wheeler, C.C. Chung, S. Mannisto, K. Yu, S.J. Chanock, D. ALbanes, Genome-wide association study of circulating vitamin D-binding protein, Am. J. Clin. Nutr. 99 (2014) 14241431. Reprinted by permission. Copyright © 2016 Elsevier Inc. All rights reserved.

Copyright © 2016 Elsevier Inc. All rights reserved. FIGURE 33.7: Interactions of bioactive food components with genes appear to be important mechanisms for carcinogenesis. From E. Trujillo, C. Davis, J. Milner, Nutrigenomics, proteomics, metabolomics and the practice of dietetics, J. Am. Diet. Assoc. 106 (2006) 403413. Copyright The American Dietetic Association. Reprinted by permission. Copyright © 2016 Elsevier Inc. All rights reserved.