Developing Neutrophils Must Eat…Themselves!

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Developing Neutrophils Must Eat…Themselves! Zhichao Fan, Klaus Ley  Immunity  Volume 47, Issue 3, Pages 393-395 (September 2017) DOI: 10.1016/j.immuni.2017.08.013 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Autophagy Fuels Neutrophil Maturation ATG5 or ATG7 are required for autophagy, which results in the release of free fatty acids (FFA) in neutrophil precursors. FFAs block glycolysis and enter the fatty acid oxidation pathway (FAO) to fuel oxidative phosphorylation (OXPHOS), producing the ATP needed for full neutrophil differentiation, maturation, and functionality. Immunity 2017 47, 393-395DOI: (10.1016/j.immuni.2017.08.013) Copyright © 2017 Elsevier Inc. Terms and Conditions

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