Increased reconstitution of human NK cells in NSG hIL-7xhIL-15 humanized mice. Increased reconstitution of human NK cells in NSG hIL-7xhIL-15 humanized.

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Increased reconstitution of human NK cells in NSG hIL-7xhIL-15 humanized mice. Increased reconstitution of human NK cells in NSG hIL-7xhIL-15 humanized mice. (A, B) Representative flow cytometry plots of (A) the BM and (B) the thymus of conventional NSG and hIL-7xhIL-15 KI NSG humanized mice (IL7xIL15). (C) Increased frequencies of CD56+ NK cells are detected in the BM, spleen, PB, and thymus of NSG hIL-7xhIL-15 KI humanized mice (BM, spleen, and PB: NSG n = 21, IL7TG n = 3, IL7KI n = 4, IL7xIL15 n = 17, thymus: NSG n = 18, IL7xIL15 n = 13). (D) Quantitative gene expression of hIL-15 by Gra1+Mac1+ mouse myeloid cells or hCD45+CD33+ human myeloid cells purified from BM of NSG (left two columns) or hIL-7xhIL-15 KI NSG (right two columns) humanized mice are presented relative to β-actin (NSG n = 3 and IL7xIL15 n = 3). (E) Representative flow cytometry plots of the BM, liver, and PB of hIL-7xhIL-15 KI NSG humanized mice showing CXCR6 expression among human NK cells. (F) Frequencies of CXCR6+CD56+ tissue-resident NK cells in the BM, liver, and PB of NSG hIL-7xhIL-15 KI humanized mice (BM n = 8, Liver n = 5, PB n = 4). Error bars represent mean ± SEM. *P < 0.001, by two-tailed t test. Masashi Matsuda et al. LSA 2019;2:e201800195 © 2019 Matsuda et al.