Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis Akira Matsuda, MD, PhD, Nobuyuki Ebihara, MD, PhD, Norihiko.

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Defective B-cell memory in patients with Down syndrome Ruud H.J. Verstegen, MD, Gertjan J. Driessen, MD, Sophinus J.W. Bartol, BSc, Carel J.M. van Noesel,

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Risk of an asthma exacerbation after bariatric surgery in adults

Fatty acids, inflammation, and asthma

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Fatty acids, inflammation, and asthma

Recurrent anaphylaxis linked to pantoprazole

Association between (CCTTT)n repeat polymorphism in NOS2 promoter and asthma exacerbations Keita Hirai, PhD, Toshihiro Shirai, MD, PhD, Masayuki Suzuki,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis Mayumi Ueta, MD, PhD, Satoshi Uematsu, MD, PhD, Shizuo Akira,

Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis George Philip, MD, Janet van Adelsberg, MD, Thomas Loeys, PhD, Nancy.

The National Biome Initiative: An allergy perspective

Physician needs in health informatics: Just ask the docs

The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases Hiroshi Fujishima, MD, Naoko Okada, PhD, Kenji.

Peter M. Wolfgram, MD, David B. Allen, MD

Profiling of human CD4+ T-cell subsets identifies the TH2-specific noncoding RNA GATA3-AS1 Huan Zhang, MD, PhD, Colm E. Nestor, PhD, Shuli Zhao, PhD,

TGF-β signaling and collagen deposition in chronic rhinosinusitis

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

What are the best outcome measurements for atopic eczema

The Editors' Choice Journal of Allergy and Clinical Immunology

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma Kawa Amin, PhD, Christer Janson, MD, PhD, Ilkka Harvima, MD,

Sharon Seth, MD, David A. Khan, MD

What is an “eosinophilic phenotype” of asthma?

Cephalosporin Side Chain Cross-reactivity

Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing Akira Matsuda, MD, PhD, Yosuke Asada, MD, PhD, Naomasa Suita, MS,

Enhanced CD46-induced regulatory T cells suppress allergic inflammation after Dermatophagoides pteronyssinus–specific immunotherapy Yi-Giien Tsai, MD,

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

Lei Wang, MD, PhD, Jesse P. Joad, MD, Caiyun Zhong, MD, PhD, Kent E

Geographic variability in childhood asthma prevalence in Chicago

Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma Pooja Takhar, PhD, Christopher J. Corrigan, MD,

Syk expression and IgE-mediated histamine release in basophils as biomarkers for predicting the clinical efficacy of omalizumab Donald W. MacGlashan,

The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection Saurabh Mehandru, MD, Klara Tenner-Racz, MD, Paul Racz, MD, PhD, Martin.

Risk of oral food challenges

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M

Measles and immunomodulation

The Editors' Choice Journal of Allergy and Clinical Immunology

IL-9 and c-Kit+ mast cells in allergic rhinitis during seasonal allergen exposure: Effect of immunotherapy Kayhan T. Nouri-Aria, PhD, FRCPath, Charles.

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Dendritic cells in nasal mucosa of subjects with different allergic sensitizations Susanne M. Reinartz, MD, Joost van Tongeren, MD, Danielle van Egmond,

Environmental factors and eosinophilic esophagitis

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Chitinases and chitinase-like proteins in TH2 inflammation and asthma

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Advances in mechanisms of allergic disease in 2016

Presentation transcript:

Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis Akira Matsuda, MD, PhD, Nobuyuki Ebihara, MD, PhD, Norihiko Yokoi, MD, PhD, Kazuichi Maruyama, MD, PhD, Junji Hamuro, PhD, Shigeru Kinoshita, MD, PhD, Akira Murakami, MD, PhD Journal of Allergy and Clinical Immunology Volume 126, Issue 6, Pages 1310-1312.e1 (December 2010) DOI: 10.1016/j.jaci.2010.06.001 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Lymphatic vessels and lymphoid neogenesis in the giant papillae. A, LYVE-1+ lymphatic vessels were observed in the substantia propria of giant papillae. B, CD20+ B-cell clusters (arrows) and T-cell zones (asterisk) were observed in the region corresponding to the lymphatic vessels. C, CD35+ FDCs were observed around the B-cell cluster. D, PNAd+ high endothelial venules were observed around lymphatic vessels. Original magnification ×200 (Fig 1, A and B) and ×400 (Fig 1, C and D). Journal of Allergy and Clinical Immunology 2010 126, 1310-1312.e1DOI: (10.1016/j.jaci.2010.06.001) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 RT-PCR analysis of the ε-chain mRNA and AID mRNA expression in the giant papillae tissues. Nested RT-PCR was carried out with cDNA specimens obtained from patients with AKC/VKC (patients 1, 3, 5, 8, and 10 in Table I). The 2% agarose gel electrophoresis showed positive bands (789 bp for ε-chain mRNA and 355 bp for AID mRNA). Journal of Allergy and Clinical Immunology 2010 126, 1310-1312.e1DOI: (10.1016/j.jaci.2010.06.001) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

IgE plasma cells and IgE+ B cells observed in the substantia propria IgE plasma cells and IgE+ B cells observed in the substantia propria. A, CD20+ B cells were observed in the substantia propria of the giant papillae, and some of the plasma cells (arrows) were IgE+. B, CD138+ plasma cells were observed in the substantia propria of the giant papillae, and some of the plasma cells (arrowhead) were IgE+. Journal of Allergy and Clinical Immunology 2010 126, 1310-1312.e1DOI: (10.1016/j.jaci.2010.06.001) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions