Smart Manipulation of Motor-Protein Movement

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Presentation transcript:

Smart Manipulation of Motor-Protein Movement Using light Nano Letters, 2001, 1 (5), pp 235–239 ACS Nano, 2014, 8 (5), pp 4157–4165 Using electric field Using ATP analogue Nano Lett., 2008, 8 (12), pp 4217–4220 Chem. Commun., 2013,49, 9935-9937

pH-responsive ATP supply system CaCO3 microspheres ATP Oxygen scavenger in motility experiment as pH inducer pH induced ATP release Multi-layer CaCO3 microspheres were synthesized by using CaCl2 and Na2CO3 solutions and coated with multi-layer film through layer by layer assembly

Properties of CaCO3 microspheres

Properties of CaCO3 microspheres

pH Triggered ATP Release in Motility Assay Motility in absence of Scavenger mixture

Conclusion Successfully employed the assembled CaCO3 microspheres as pH response ATP carriers. After incubating with ATP, these microspheres were used as energy source to power the kinesin-microtubule system. These microspheres can be further used to load other cargo besides ATP to work as self powered cargo delivery nano-machines

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