Cyp8b1−/− mice have an altered circulating bile acid pool.

Slides:

Advertisements

Similar presentations

Volume 15, Issue 1, Pages (January 2012)

Advertisements

Figure 2. Plasma lipoprotein cholesterol in apo-E −/− mice with CRF

Figure 1. Plasma urea concentrations in apolipoprotein E–deficient (apo-E −/−) mice with chronic renal failure (CRF). Figure 1. Plasma urea concentrations.

INT-767 treatment regulates kidney bile acid composition, bile acid synthesis, and bile acid transporters in high-fat diet–induced obesity mice. INT-767.

Figure 2 13C-octanoic acid gastric emptying breath test

Postprandial glucose flux in nondiabetic controls.

Hematological alterations after endotoxin injection.

Urine ammonia is highly correlated with plasma K

Changes throughout time in the lineage content of clones regenerated in secondary mice. Changes throughout time in the lineage content of clones regenerated.

Hyperinsulinemic-euglycemic clamps revealed that obese TPL2KO mice have an improved insulin sensitivity compared with obese WT mice. Hyperinsulinemic-euglycemic.

Cyp8b1−/− mice have improved islet insulin secretion and increased islet insulin content but unchanged β-cell mass. Cyp8b1−/− mice have improved islet.

A–L: Xenin-25 amplifies the effects of GIP on plasma insulin, C-peptide, and glucose levels and ISRs in humans with NGT and IGT but not T2DM. A–L: Xenin-25.

Overexpression of BTG2 resulted in an increase in hepatic gluconeogenesis. Overexpression of BTG2 resulted in an increase in hepatic gluconeogenesis. A:

Deletion of neuronal insulin receptor signaling reduces TG secretion, while the targeted knockout of insulin receptors restricted to the periphery increases.

Skeletal muscle sarcoplasmic protein FSR

Liver mitochondrial protein FSR

A and B: Plasma levels of IR-GIP and xenin-25 during GGIs

Glucose, insulin, and AGE levels during an OGC before and after RT

Exogenous CRP administration causes fasting hyperglycemia and hyperinsulinemia without altering body composition. Exogenous CRP administration causes fasting.

Plasma glucose (A) and glucose specific activity (B) during euglycemic clamp experiments. Plasma glucose (A) and glucose specific activity (B) during euglycemic.

TG-CRP mice display fasting hyperglycemia, hyperinsulinemia, and insulin resistance. TG-CRP mice display fasting hyperglycemia, hyperinsulinemia, and insulin.

Liver AMPK is activated by oral administration of canagliflozin in mice, but this does not explain changes in RER. A: Phosphorylation of AMPK, ACC, and.

Sox4 promotes hepatic TG accumulation in vivo.

A: The change of plasma glucose in opioid μ-receptor knockout diabetic mice and wild-type controls receiving an oral intake of metformin (100 mg/kg). A:

N-3 resolution mediators improve insulin signaling by blunting JNK and iNOS in muscle and liver. n-3 resolution mediators improve insulin signaling by.

Left columns: Plasma glucose and serum insulin concentrations, circulating TF-PCA, and FVIIa activity before and during 24 h of selective hyperglycemia.

Mean ± SEM concentration of insulin in plasma and CSF and glucose in plasma 30 min after the intraperitoneal administration of DET or NPH insulin at different.

Appearance of insulin in plasma and CSF at different times after the administration of subcutaneous DET and GLAR in mice and the effect of chronic DET.

TXNIP and caspase-1 protein levels are increased in the adipose tissue of ob/ob mice. TXNIP and caspase-1 protein levels are increased in the adipose tissue.

Late gestational SF exposures alter miR-103/107 expression profiles and their target protein Cav1 in VWAT of offspring mice. Late gestational SF exposures.

IRS-1 and -2 expression in four mesangial cell lines from different D-NOD (A and B) and ND-NOD (C and D) mice. IRS-1 and -2 expression in four mesangial.

Plasma levels of GLP-1 are increased in patients with critical illness and correlate with disease severity. Plasma levels of GLP-1 are increased in patients.

Glucose tolerance in WT and TRPM2-KO mice.

Transgenic restoration of long-chain n-3 PUFA protects against obesity-linked insulin resistance and glucose intolerance. Transgenic restoration of long-chain.

The underlying physiological basis of the HOMA model.

Correlation of muscle Rg' with circulating triglyceride levels and local LCACoAs content in the clamp state. Correlation of muscle Rg' with circulating.

Insulin levels are increased in the MBH of Ugcgf/f//CamKCreERT2 mice.

Starvation-induced inhibition of leptin transport across the BBB is caused by a circulating factor. Starvation-induced inhibition of leptin transport across.

Linearity of the relationships between spectral abundance factors observed when 30 and 120 μg protein were analyzed, as described in research design and.

Knockout of SIRT1 in podocytes aggravates proteinuria and kidney injury in db/db mice. Knockout of SIRT1 in podocytes aggravates proteinuria and kidney.

The effect of VSG on body weight and body fat in GLP-1r KO mice.

A: Chemical structure of pterosin A

ATL-801 treatment increases insulin sensitivity in KKAY mice.

Chop deletion preserves β-cell function in P58IPK−/− mice.

Total plasma BCAA (A) and C3 and C5 acylcarnitine (AC) (B) concentrations in the basal state and during insulin infusion in obese subjects before and after.

USP2–45 regulates hepatic gluconeogenesis.

SENP2 overexpression increases FAO by upregulating expression of FAO-associated enzymes in muscle. SENP2 overexpression increases FAO by upregulating expression.

Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice.

Hepatic fuel metabolism in male 5αR1-KO and WT mice

Hepatic PPARγ deficiency impairs the SCFA-induced reduction in hepatic steatosis. Hepatic PPARγ deficiency impairs the SCFA-induced reduction in hepatic.

Insulin resistance and hepatic steatosis in ASKO mice.

Treatment of high-fat diet–fed mice with TTR-ASOs decreases circulating TTR and RBP4 levels, and improves insulin sensitivity. Treatment of high-fat diet–fed.

Treatment of ob/ob mice with TTR-ASOs improves insulin sensitivity.

Effects of Rosi treatment on ASKO mice.

Metabolic effects of VSG in GLP-1r KO mice.

Plasma glucose, GIR, rates of EGP and glucose utilization, and plasma concentrations of free fatty acids (FFAs) and β-hydroxy-butyrate after a subcutaneous.

GTTs and ITTs. A: GTTs of WT (◇), LepTg (♦), Akita (open circles), and LepTg:Akita (closed circles) mice at 8 and 16 weeks of age. GTTs and ITTs. A: GTTs.

Arterial and hepatic sinusoidal plasma insulin levels in conscious dogs during the basal (−40 to 0 min) and experimental (0–240 min) periods treated with.

Loss of Phb2 in β-cells induces development of diabetes over a 3-week period in β-Phb2−/− mice. Loss of Phb2 in β-cells induces development of diabetes.

Anti-DNA Abs were not affected by the deletion of GCs in pristane-induced lupus model. Anti-DNA Abs were not affected by the deletion of GCs in pristane-induced.

Forest plot and pooled estimates of the effect of NAFLD on the risk of incident diabetes in 16 eligible studies, stratified by length of follow-up (FU)

A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R.

Progressive IGF-1 liver expression, β-cell hyperplasia, and defective insulin secretion with aging in inducible liver-specific insulin receptor knockout.

Flow diagram illustrating diabetes outcomes in the randomly assigned treatment of folic acid and vitamins B6 and B12 of the WAFACS. A total of 1,190 participants.

Pooled analysis of association between (nonexclusive) breast-feeding and childhood-onset type 1 diabetes in studies investigating ∼2 weeks (nonexclusive)

Doses of trial medication in the liraglutide groups (A) and in the placebo groups (B). Doses of trial medication in the liraglutide groups (A) and in the.

Nested RT-PCR of Mammaglobin and CK19 mRNA in plasma and circulating cells of controls (C) and patients (T) with breast cancer. Nested RT-PCR of Mammaglobin.

GM-CSF is required for CA-MSC–induced tumor metastasis.

Γ-TmT reduces serum E2 levels and induces estrogen-metabolizing enzyme CYP1A1 in E2-treated ACI rats. γ-TmT reduces serum E2 levels and induces estrogen-metabolizing.

A: Detection of insulin aspart and insulin lispro by the Iso-insulin ELISA method. A: Detection of insulin aspart and insulin lispro by the Iso-insulin.

Presentation transcript:

Cyp8b1−/− mice have an altered circulating bile acid pool. Cyp8b1−/− mice have an altered circulating bile acid pool. A: Plasma bile acid pool in control (+/+) and Cyp8b1−/− (−/−) mice (n = 3–5). HDC, hyodeoxycholic acid. B: Hepatic transcript levels of Cyp7a1, Cyp27a1, and Cyp8b1 in control (+/+) and Cyp8b1−/− (−/−) mice (n = 4–5). Data are shown as mean ± SEM. ND, not detectable. *P < 0.05 and **P < 0.01, by Student t test. Achint Kaur et al. Diabetes 2015;64:1168-1179 ©2015 by American Diabetes Association