Treatment of HCMT-CMs with bisoprolol.

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Treatment of HCMT-CMs with bisoprolol. Treatment of HCMT-CMs with bisoprolol. (A-E) Quantification of the occurrence of arrhythmia in the presence of 0.5 nM adrenaline (0.5 nM A), with addition of 1 μM (0.5 nM A+1 μM B) and 10 μM (0.5 nM A+10 μM B) bisoprolol. (F-I) Summary of SD1, SD2, STV-APD50 and STV-APD90 in the presence of 0.5 nM adrenaline with addition of 1 μM and 10 μM bisoprolol (n=14 for 0.5 nM A, n=4 for 0.5 nM A+1 μM B and n=7 for 0.5 nM A+10 μM B). (J-N) Quantification of the occurrence of arrhythmia during the wash-out condition of 0.5 nM adrenaline with 0 μM (no B), 1 μM (1 μM B) and 10 μM (10 μM B) bisoprolol (n=24 for 0.5 nM A/no B, n=9 for 0.5 nM A+1 μM B/1 μM B and n=15 for 0.5 nMA+10 μM B/10 μM B). Chandra Prajapati et al. Dis. Model. Mech. 2018;11:dmm032896 © 2018. Published by The Company of Biologists Ltd