Raw data from one individual where each 60 s cycle has been time aligned. Raw data from one individual where each 60 s cycle has been time aligned. The far left hand panel is 240 s of baseline ventilation where no intervention has taken place. The middle panel is the data from cardiac output oscillations alone every thirty seconds resulting in oscillations in the respiratory gases and ventilation. The right hand panel shows five time-aligned cycles where dynamic CO2 therapy was applied coincident with peak ventilation while 60 s cardiac output alternation continued and the resultant amplitude of end-tidal CO2 and ventilatory oscillations were attenuated. Resham Baruah et al. Open Heart 2014;1:e000055 ©2014 by British Cardiovascular Society