Superimposed traces representing the effects of different concentrations of adrenaline on AP characteristics. Superimposed traces representing the effects.

Slides:

Advertisements

Similar presentations

Mitochondria localize to both the front and the rear of neutrophils.

Advertisements

SESN2 expression in lungs from healthy donors, habitual smokers without COPD and individuals with late-stage COPD. (A) Representative western blots of.

Leukemia involves the accumulation of ISP CD8+T-cells and blockages in B-cell development. Leukemia involves the accumulation of ISP CD8+T-cells and blockages.

Effect of cxcr3.2 mutation on dissemination of local mycobacterial infection within 24 hpi. Effect of cxcr3.2 mutation on dissemination of local mycobacterial.

Fig. 3. Effect of NH4Cl (0 or 30 mM) on percentage of motile spermatozoa and VAP after 1 and 5 min after activation. Effect of NH4Cl (0 or 30 mM) on percentage.

Fig. 2. Proportion of motile objects and track length

Representative histological images of aorta from WT, ApoEm/m and ApoE−/− pigs. Representative histological images of aorta from WT, ApoEm/m and ApoE−/−

A Drosophila cell culture model to study VAP(P58S) aggregation.

OA and related amines modulate motility and length of schistosomula.

Effects of embryonic hypoxia on fasted and postprandial cardiac shunting. Effects of embryonic hypoxia on fasted and postprandial cardiac shunting. Mean.

Fig. 4. Effects of ion deprivation on percentage of motile spermatozoa and VAP after 1 and 5 min after activation. Effects of ion deprivation on percentage.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Concentration of biomarkers of haemostasis.

TP53 western blot of primary cultured tail cells from both wild-type (WT) and Tp53Δ11/Δ11 (−/−) rats. TP53 western blot of primary cultured tail cells.

Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC. Ingenuity pathway analysis of the genes enriched in both 96-h-induced.

Asj-2J mice show a progressive age-dependent increase in calcification in aorta, muzzle skin containing the dermal sheath of the vibrissae, kidney, spleen.

Pie charts showing the percentage of genes for selected enriched biological functions and pathways at different time points after hyperthermic seizures.

TWEAK downregulates SIRT3 in cultured tubular cells and this is prevented by crotonate. TWEAK downregulates SIRT3 in cultured tubular cells and this is.

Fig. 4. Brood size of four successive births by male seahorses Hippocampus erectus in the two groups (TR-1, TR-2).In TR-1 groups: male and female seahorses.

Behavioral test parameters.

Obesity affected the metabolic response to stroke.

Silencing of Keap1 reduced the expression of inflammatory markers in ConA-injected livers. Silencing of Keap1 reduced the expression of inflammatory markers.

Increased osteoclastogenesis in the mandibular bone of Fgfr2+/S252W embryos at E16.5. Increased osteoclastogenesis in the mandibular bone of Fgfr2+/S252W.

Treatment of HCMT-CMs with bisoprolol.

Heatmap of relative expression levels of 75 O

Voltage-gated ionic currents in ventricle-like WT-CMs, HCMT-CMs and HCMM-CMs. Voltage-gated ionic currents in ventricle-like WT-CMs, HCMT-CMs and HCMM-CMs.

The effect of TDP-43A315T expression on dendrite spine development.

Distribution and extent of expression.

Intestinal CAV1 deletion alters circulating FFAs but not TGs

FAK/Src activity is required to trap PTP1BDA in adhesions.

The genomic distribution of essential and non-essential mouse genes, separated into known and predicted essentiality. The genomic distribution of essential.

Table 1. Effects of flatworm presence and prey concentration on coral feeding rates and flatworm behaviour.Two-way mixed factorial ANOVA, showing main.

Loss of LAR phosphatase activity is associated with decreased adhesion complex formation. Loss of LAR phosphatase activity is associated with decreased.

TWEAK increases histone crotonylation in kidney tubular cells.

The effect of TDP-43A315T expression at the synapse.

Biphasic ambulatory activity and reduced avoidance in Id2−/− mice.

Homozygous col22a1−/− embryos show increased percentage of hemorrhages when raised at increased temperature. Homozygous col22a1−/− embryos show increased.

Tissue ATP levels measured in the liver, muscle, kidney and pancreas of CDs/y and CDr/y on RD or DD. *P

Increased expression of the drusen-associated genes (ApoE, ApoJ, ApoB and App) and Vegfa in the RPE/retina of Pgc-1α+/− mice under RD and HFD. (A) The.

Compensatory hyperinsulinemia maintains euglycemia in HFHC-fed guinea pigs but is lost with STZ treatment. Compensatory hyperinsulinemia maintains euglycemia.

Macrophage-produced IL-10 is required but not sufficient for macrophage-stimulated proliferation of ADPKD cells. Macrophage-produced IL-10 is required.

Food-additive exposure increases permeability in a human gut cell co-culture model. Food-additive exposure increases permeability in a human gut cell co-culture.

Food-additive exposure reduces adult fly survival under some feeding conditions. Food-additive exposure reduces adult fly survival under some feeding conditions.

Effect of γ-secretase inhibition on the vulnerability of primary neurons to OGD. (A) Experimental design. Effect of γ-secretase inhibition on the vulnerability.

Decreasing sleep levels using dTRPA1-based reversible activation of dopaminergic neurons reversibly decreases egg output. Decreasing sleep levels using.

Impact of maternal loading for GALK on survival of larvae to adulthood in the presence versus absence of 200 mM dietary galactose. Impact of maternal loading.

Anti-epileptic drugs with Na+ channel blocking activity improve QTc in individuals with Rett syndrome. Anti-epileptic drugs with Na+ channel blocking activity.

Drs expression profiles for OreR flies infected with the various C

HEK-cFXN cells show a correlation among ROS levels, LIP and frataxin expression. HEK-cFXN cells show a correlation among ROS levels, LIP and frataxin expression.

Guinea pigs fed HFHC diet develop impaired glucose tolerance and suppressed response to insulin. Guinea pigs fed HFHC diet develop impaired glucose tolerance.

Cross-validation between centres for inbred mice.

Pgc-1α+/− mice show an increased inflammatory response to LPS injection. Pgc-1α+/− mice show an increased inflammatory response to LPS injection. (A) RPE/retina.

Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants. Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants.

fmn flies reduce sleep but not egg output in response to caffeine.

ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. ALS-CSF induces atrophy of type 2 fibres in EDL muscle of neonatal rats. (A,B)

Fig. 2. Effects of pH on percentage of motile spermatozoa and VAP after 1 and 5 min after activation. Effects of pH on percentage of motile spermatozoa.

Effects of dietary sucrose and fat on the expression of metabolic and stress-response genes in knee cartilage. Effects of dietary sucrose and fat on the.

Marginal means (±s.e.m.) of temperatures for four tissues in 13 king penguins while fasting in water. Marginal means (±s.e.m.) of temperatures for four.

Peroxisome speeds were slower in patient and control cells.

The influence of SHIP2 on cell migration in breast cancer cells.

The vps13 mutants are hypersensitive to SDS but cell wall integrity is not compromised. The vps13 mutants are hypersensitive to SDS but cell wall integrity.

Summary of variabilities in hiPSC-CMs.

Effect of siRNA transfection on colony formation by Renca cells.

Decreased enzymatic activity in PKG mutants increases time to recovery from an electroshock. Decreased enzymatic activity in PKG mutants increases time.

Graphical representation of pain levels versus time postinjury, annotated across control, persistently hypersensitive genotypes and diabetic conditions,

Functional and molecular regeneration in mdx muscle with matrix treatment. Functional and molecular regeneration in mdx muscle with matrix treatment. (A,B)

Regulation of Bcl-2 family proteins in the hypothalamus of non-diabetic and diabetic IRS2−/− mice. Regulation of Bcl-2 family proteins in the hypothalamus.

Octreotide (OCT) concentrations mixed with metoclopramide (MET) containing or not containing sodium bisulfate (SBS) for 10 days after being prepared. Octreotide.

Time courses of octreotide (OCT) concentrations depended on sodium bisulfate (SBS) concentrations. Time courses of octreotide (OCT) concentrations depended.

Pharmacodynamic and pharmacokinetic evaluation of EXE-RM-LNC in a high-fat diet (HFD)-induced obese/diabetic mouse model following acute treatment. Pharmacodynamic.

Presentation transcript:

Superimposed traces representing the effects of different concentrations of adrenaline on AP characteristics. Superimposed traces representing the effects of different concentrations of adrenaline on AP characteristics. (A-F) Percentage change in BPM (A), APD50 (B), APD90, (C) MDP, (D) APA (E) and dV/dt (F), with respect to pre-adrenaline administration condition in WT-CMs, HCMT-CMs and HCMM-CMs. One concentration of adrenaline was tested at a time. Data are mean±s.e.m. *P<0.05, WT versus HCMT or HCMM; #P<0.05, HCMT versus HCMM; one-way ANOVA, post hoc Tukey test. Table shows the number of cells used in each group at different adrenaline concentrations. (For more detail, see Tables S4-S7.)‏ Chandra Prajapati et al. Dis. Model. Mech. 2018;11:dmm032896 © 2018. Published by The Company of Biologists Ltd