Fig. 8. Lhx1-RNAi perturbs NR formation

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Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development Introduction Lhx2 is a member of the LIM homeodomain.
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From: Induction of Functional 3D Ciliary Epithelium–Like Structure From Mouse Induced Pluripotent Stem Cells Invest. Ophthalmol. Vis. Sci ;57(1):
Volume 5, Issue 6, Pages (June 2002)
Identification of vegetally localised vrtn transcripts.
Development of the eye:
Ocular defects produced by Daam1 mutation and in combination with diabetes. Ocular defects produced by Daam1 mutation and in combination with diabetes.
Altered Melanocyte Differentiation and Retinal Pigmented Epithelium Transdifferentiation Induced by Mash1 Expression in Pigment Cell Precursors  Jessica.
Figure 2 Optical coherence tomography of the human retina A) Detailed retinal segmentation sample on spectral-domain optical coherence tomography (OCT)
Giant Eyes in Xenopus laevis by Overexpression of XOptx2
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Posterior part of the eye Review
Volume 8, Issue 4, Pages (April 2005)
Neovascularization, macular edema and retinal detachments in the vhl−/− retina. Neovascularization, macular edema and retinal detachments in thevhl−/−retina.
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Fig. 8. In vitro effect of CMPs on adult DSS-treated stomach explants.
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Aberrant development of the anterior segment in AP-2β NCC KO mutants.
Fig. 5. Ovary of the white shark Carcharodon carcharies.
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Fig. 7. Knockdown of Meis1 abolishes CR4. 2-GFP expression
Embryonic corneal defects in E18.5 AP-2β NCC KO mutant embryos.
Fig. 5. Meis1 transcription factor is essential for CR4
Hipk induces cell spreading.
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Fig. 8. Knockdown of Meis1 reduces the expression of Foxn4 and Lim1+2
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Fig. 7. Lhx1-RNAi reduces the eye size
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Fig. 5. UV reflections from the eye cup.
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Fig. 6. STK35 KO mice show ovary defects.
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The notochord and the peri-notochordal basement membrane.
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Fig. 8. Lhx1-RNAi perturbs NR formation Fig. 8. Lhx1-RNAi perturbs NR formation.(A–E) Hematoxylin-Eosin staining at stage 24. Lhx1-RNAi perturbs NR formation.(A–E) Hematoxylin-Eosin staining at stage 24. (B) Magnified view of the posterior retina in (A); distinct pigmentation is observed on the basal side of the single-layered RPE. (C) Small eye phenotype after Lhx1-RNAi, in which a pigmented vesicle (pv) forms and lens (le) development is perturbed. (D) The optic epithelium abutting the lens. (E) Posterior optic epithelium with distinct polarized pigmentation. (F–M) Expression of Chx10, Otx2, Mitf, and Mmp115. Eyes were examined at 24 hours (F,G,J,K), 36 hours (H,L) or 60 hours post-electroporation (I,M). In situ hybridization was performed under the same conditions for controls and Lhx1-RNAi, depending on the probes. (J) Chx10 expression in the inner layer of the optic cup is reduced (arrowhead). (K) The Otx2 expression domain is expanded to the inner layer of the optic cup (arrowhead). (L) Mitf expression is detected in the inner layer as well as outer layer of the optic cup. (M) Mmp115 expression is detected in the dorsal epithelium of the OV (arrowheads) and abutting the lens vesicle (arrow). The axis of the eye is depicted as follows: A, anterior; D, dorsal; P, posterior; V, ventral; nr, neural retina; and rpe, retinal pigmented epithelium. Scale bars, 100 µm (A,C), 10 µm (B,D,E). Takumi Kawaue et al. Biology Open 2012;1:1083-1093 © 2012. Published by The Company of Biologists Ltd