Shruti Mishra, Brian Andrew Gordon, Karl A

Slides:



Advertisements
Similar presentations
2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.
Advertisements

Sleep disruption changes across the disease trajectory: Pilot findings from the healthy patterns sleep study Nancy A. Hodgson, Albert J. Safi Alzheimer's.
Capillary dysfunction in Alzheimer's disease
DIAGNOSTIC ACCURACY AND CONFIDENCE IN THE CLINICAL DETECTION OF COGNITIVE IMPAIRMENT IN EARLY-STAGE PARKINSON’S DISEASE  Kathryn A. Wyman-Chick, Phillip.
Vladimir S. Fonov, Mahsa Dadar, Xiao Yiming, D. Louis Collins 
Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene- dependent?  Kirsi Kinnunen, Natalie Ryan, David Cash, António Bastos.
Relationship between Microstructural Degeneration of the Corpus Callosum, White Matter Hyperintensities, and Motor Function in Cognitively Intact Elderly 
Hilkka Liedes, Jyrki Lötjönen, Gerald P. Novak, Mark Forrest Gordon 
Different pathways to Alzheimer’s disease
A SYSTEMATIC REVIEW AND META-ANALYSIS COMPARING QUALITY-OF-LIFE RATINGS FROM FAMILY AND PAID CAREGIVERS OF PEOPLE WITH DEMENTIA RESIDING IN CARE HOMES 
Mutation frequency of pathogenic genes in familial Alzheimer’s disease in China  Jianping Jia, Liyong Wu, Wei Qin, Dan Li, Luxi Shen, Hanzhi Li, Qianqian.
Correlations between amyloid and metabolic pet imaging in cognitively normal adults with a family history of late-onset Alzheimer's disease  Megan Cummings,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Trajectory of multi-dimensional caregiving burden in chinese informal caregivers for dementia: Evidence from exploratory and confirmatory factor analysis.
Interaction network of tau protein, beta-amyloid protein, and amyloid protein precursor under oxidative stress in Alzheimer’s disease  Eduardo de Souza/S.
The differential diagnosis of amnestic mild cognitive impairment and Alzheimer's disease dementia by hippocampal volume measurement with MR in a chinese.
Localization of Hippocampal atrophy in Alzheimer's disease
INVESTIGATION OF 99MTC-LABELED CLIOQUINOL DERIVATIVE ON AMYLOID PLAQUE SPECIFICITY BY USING AN ANIMAL MODEL OF ALZHEIMER'S DISEASE  Ayfer Yurt KIlçar,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
A NOVEL NEUROIMAGING APPROACH TO CAPTURE COGNITIVE RESERVE
Christine Bredfeldt, Kristen Rice, Lisa Alecxih 
Comparison of tract-based spatial statistics and ROI-based approach in analyzing the white matter integrity in the elderly  Huali Wang, Daniel Chang,
KETOGENIC DIET EFFECTS ON BRAIN KETONE METABOLISM AND ALZHEIMER'S DISEASE CSF BIOMARKERS  Suzanne Craft, Bryan J. Neth, Akiva Mintz, Kiran Sai, Nora Shively,
The effect of using a conditional discrimination procedure to teach name-face relation to a person diagnosed with dementia  Hanna S. Steingrimsdottir,
Alzheimer's disease biomarker-based clusters predict amyloid accumulation and cognitive decline in a preclinical cohort: Findings from the wisconsin registry.
Application of Resource Utilization in Dementia (RUD) instrument in a global setting  Anders Wimo, Anders Gustavsson, Linus Jönsson, Bengt Winblad, Ming-Ann.
DATA-DRIVEN TAU-PET COVARIANCE NETWORKS ENHANCE PREDICTION OF RETROSPECTIVE COGNITIVE CHANGE IN ALZHEIMER’S DISEASE  Jacob W. Vogel, Niklas Mattsson,
LATENT-FACTOR STRUCTURE OF THE DELCODE STUDY NEUROPSYCHOLOGICAL TEST BATTERY  Steffen Wolfsgruber, Luca Kleineidam, Jannis Guski, Oliver Peters, Katharina.
APOE GENOTYPE MODIFIES THE EFFECTS OF AEROBIC TRAINING ON BRAIN GLUCOSE METABOLISM IN SUBJECTS WITH MILD COGNITIVE IMPAIRMENT  Fabio H.G. Porto, Artur.
HYPERGLYCEMIA: PREDISPOSITION FOR MICROEMBOLI, STROKE, AND WHITE MATTER CHANGES  Leila Parand, Saif Bushnaq, Yue Wang, Lenora Mathes, Dinesh Jillella,
Marjolein Bulk, Linda van der Graaf, Walid M
Colin Groot, Chris W. J. van der Weijden, Wiesje M
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Japanese brain bank network for neuroscience research
BIOLOGICAL PATHWAYS FOUND IN COMMON BETWEEN ALZHEIMER’S DISEASE AND MAJOR DEPRESSION: A STUDY ON MICRORNA EXPRESSION IN A SYSTEMATIC REVIEW  Ana Paula.
DUAL FUNCTIONAL NANOPARTICLES FOR M1 ACETYLCHOLINE RECEPTOR SELECTIVE ALLOSTERIC POTENTIATOR TO TARGET AMYLOID PLAQUES IN THE BRAIN OF STREPTOZOTOCIN-INDUCED.
Volume 17, Issue 3, Pages (March 2018)
Community environment and incident dementia: Results from the three-city study  Claudine Berr, Laure Anne Gutierrez, Sylvaine Artero, Catherine Helmer,
Pairwise gene-protein association analysis on CSF proteomics in the ADNI-1 cohort  Sungeun Kim, Shanker Swaminathan, Kwangsik Ngo, Shannon Risacher, Li.
Effect of hypertension and antihypertensive medication on executive function, brain atrophy, and white matter hyperintensities  Shannon L. Risacher, Li.
Application of Resource Utilization in Dementia (RUD) instrument in a global setting  Anders Wimo, Anders Gustavsson, Linus Jönsson, Bengt Winblad, Ming-Ann.
Volume 17, Issue 3, Pages (March 2018)
LIFESPAN OF ONE FOCUSED ULTRASOUND MEDIATED BLOOD-BRAIN BARRIER TREATMENT IN A MOUSE MODEL OF ALZHEIMER'S DISEASE  Charissa Poon, Kullervo Hynynen  Alzheimer's.
Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective  Matthew Baumgart, Heather M. Snyder,
Comparison of visual and quantitative florbetapir-PET reads in subjects with early Alzheimer's disease for assessing amyloid burden  Bradley Wyman, Yahong.
Sulantha S. Mathotaarachchi, Tharick A
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
The incremental diagnostic value of 18F-florbetapir imaging in naturalistic patients with cognitive impairment: The India-FBP study  Marina Boccardi,
Added value of 11C-PiB-PET imaging in the diagnosis of Alzheimer's disease  Kristian Frederiksen, Anne-Mette Hejl, Ian Law, Steen Hasselbalch, Gunhild.
Mark D. Meadowcroft, Douglas G. Peters, Carson J
COGNITIVE COMPLAINTS IN OLDER ADULTS AT RISK FOR ALZHEIMER’S DISEASE ARE ASSOCIATED WITH ALTERED RESTING STATE NETWORKS  Joey A. Contreras, Joaquín Goñi,
Distinct [18F]AV1451 retention patterns in clinical variants of Alzheimer’s disease  Rik Ossenkoppele, Daniel Schonhaut, Suzanne Baker, Andreas Lazaris,
MR-less cortical surface-projection of PET images from 11C- and 18F-labeled radiotracers  Vincent Doré, Pierrick Bourgeat, Luping Zhou, Jurgen Fripp,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
GREY MATTER CONNECTIVITY IS ASSOCIATED WITH CLINICAL PROGRESSION IN NON-DEMENTED, AMYLOID POSITIVE PATIENTS  Betty M. Tijms, Mara ten Kate, Sander C.J.
DIFFERENCES IN ANALYTICAL SELECTIVITY OF β-AMYLOID (1-42) IMMUNOASSAYS EXPLAIN DISCORDANT RESULTS IN STUDY COMPARISONS  Hugo Marcel Vanderstichele, Emeric.
Alzheimer's Association towards Guidelines for Dementia Care Practice: Recommendations with emphasis on high-quality, person-centered care in long-term.
Brain amyloid deposition and metabolism in early and late mild cognitive impairment  Jared Rowley, Liyong Wu, Sara Mohades, Marina Dauar, Antoine Leuzy,
Tharick A. Pascoal, Sulantha S
Different pathways to Alzheimer’s disease
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Suzanne E. Schindler, Julia D. Gray, Brian A
INTRINSIC CONNECTIVITY NETWORKS IN POSTERIOR CORTICAL ATROPHY: A ROLE FOR THE PULVINAR?  Carolyn A. Fredericks, Jesse Brown, Jersey Deng, Rik Ossenkoppele,
Automated detection of beta-amyloid–related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI 
Extracting white matter hyperintensities in Alzheimer's disease risk and aging studies using supervised segmentation methods  Vamsi Ithapu, Vikas Singh,
BRAIN AMYLOIDOSIS AND COGNITIVE DECLINE IN MCI: 12-MONTH FOLLOW-UP
Replication and meta-analysis of the CHRFAM7A copy number variant in a cohort of clinically characterized and neuropathologically verified individuals 
Michael Navitsky, Abhinay D. Joshi, Michael D. Devous, Michael J
ONE-YEAR GLOBAL OUTCOME OF A COMPREHENSIVE, INDIVIDUALIZED, PERSON CENTERED MANAGEMENT (CI-PCM) PROGRAM + MEMANTINE IN ADVANCED AD: A RANDOMIZED CONTROLLED.
CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER.
Presentation transcript:

CLASSIFYING TAU PET POSITIVITY WITH [18F]-AV-1451 IN PRECLINICAL ALZHEIMER'S DISEASE  Shruti Mishra, Brian Andrew Gordon, Karl A. Friedrichsen, Yi Su, Jon Christensen, Patricia Aldea, Nigel J. Cairns, John C. Morris, Beau Ances, Tammie LS. Benzinger  Alzheimer's & Dementia: The Journal of the Alzheimer's Association  Volume 12, Issue 7, Pages P2-P3 (July 2016) DOI: 10.1016/j.jalz.2016.06.063 Copyright © 2016 Terms and Conditions

Figure 1 Mean weight for ROIs across 500 simulations of sparse k-means algorithm when clustering CN participants into k=2 groups Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, P2-P3DOI: (10.1016/j.jalz.2016.06.063) Copyright © 2016 Terms and Conditions

Figure 2a Relationship between mean AV-1451 SUVR and episodic memory Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, P2-P3DOI: (10.1016/j.jalz.2016.06.063) Copyright © 2016 Terms and Conditions

Figure 2b Relationship between mean AV-1451 SUVR and visual spatial memory Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, P2-P3DOI: (10.1016/j.jalz.2016.06.063) Copyright © 2016 Terms and Conditions

Figure 2c Relationship between mean AV-1451 SUVR and attentional control Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, P2-P3DOI: (10.1016/j.jalz.2016.06.063) Copyright © 2016 Terms and Conditions

Figure 3 Mean AV1451 SUVR in PET Amyloid Positive vs. Negative Participants Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, P2-P3DOI: (10.1016/j.jalz.2016.06.063) Copyright © 2016 Terms and Conditions

Figure 4 Difference in AV45 mcSUVR in Tau Positive vs. Tau Negative CN Participants Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, P2-P3DOI: (10.1016/j.jalz.2016.06.063) Copyright © 2016 Terms and Conditions