Fig. 3 Sortilin deletion unmasks NTSR2 signaling.

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Fig. 3 Sortilin deletion unmasks NTSR2 signaling. Sortilin deletion unmasks NTSR2 signaling. (A) PWT to tactile stimuli of WT and Sort1−/− mice before and after SNI and intrathecal SR142948A injection. ***P < 0.0004 and ****P < 0.0001, versus the contralateral side of Sort1−/− mice; n = 6 to 8, two-way RM ANOVA with post hoc Dunnett’s test [F(3,24) = 35.53, P < 0.0001], means ± SEM, with syringes representing double injections per day. (B) PWT to tactile stimuli of Sort1−/− mice before and after intrathecal BDNF ± SR142948A injection. **P < 0.009 and ***P < 0.0008; n = 6, two-way RM ANOVA with post hoc Sidak’s test [F(1,10) = 10.49, P = 0.0089], means ± SEM, with the syringe representing double intraperitoneal SR142947A injections on days −2, −1, and 0 and one intrathecal BDNF injection on day 0, 1 hour before testing. (C) KCC2 levels in ipsilateral L3-L5 SDH of Sort1−/− mice with and without intrathecal SR142948A injection 6 days after SNI. n = 3, paired t test, means ± SEM. (D) PWT to tactile stimuli of Sort1−/− mice before and after SNI and intraperitoneal SR48692. n = 6, two-way RM ANOVA with post hoc Dunnett’s test, means ± SEM, with syringes representing double injections per day. (E) PWT to tactile stimuli of Sort1−/− mice before and after SNI and intraperitoneal levocabastine. ***P < 0.0003 and ****P < 0.0001; n = 7, two-way RM ANOVA with post hoc Dunnett’s test [F(3,24) = 39.06, P < 0.0001], means ± SEM, with syringes representing single injections. Mette Richner et al. Sci Adv 2019;5:eaav9946 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).