Diabetes-induced impairment in angiogenic capacity in subcutaneous sponge implants. Diabetes-induced impairment in angiogenic capacity in subcutaneous.

Slides:

Advertisements

Similar presentations

Journal of Surgical Research

Advertisements

Different effects of catechin on angiogenesis and inflammation depending on VEGF levels Rita Negrão, Raquel Costa, Delfim Duarte, Tiago Taveira Gomes,

Vascular Endothelial Growth Factor (VEGF)-Mediated Angiogenesis Is Associated with Enhanced Endothelial Cell Survival and Induction of Bcl-2 Expression

Ultraviolet B-Induced Skin Angiogenesis Is Associated with a Switch in the Balance of Vascular Endothelial Growth Factor and Thrombospondin-1 Expression

by Johannes B. K. Schwarz, Nicolas Langwieser, Nicole N

Platelet TGF-β1 deficiency decreases liver fibrosis in a mouse model of liver injury by Shahrouz Ghafoory, Rohan Varshney, Tyler Robison, Karim Kouzbari,

Fig. 6. AZD6738 induces DNA damage and apoptosis and exhibits antitumor efficacy in xenograft models of high-risk medulloblastoma and neuroblastoma. AZD6738.

Ocular defects produced by Daam1 mutation and in combination with diabetes. Ocular defects produced by Daam1 mutation and in combination with diabetes.

Volume 134, Issue 4, Pages e2 (April 2008)

Fibroblast activation in WT and NFATc2-deficient mice.

Silver acetate coating promotes early vascularization of Dacron vascular grafts without inducing host tissue inflammation Pascal Jeanmonod, MD, Matthias.

Fig. 1. NASH and fibrosis develop late in mice fed an HFD.

Post-transcriptional deregulation of hnRNPH3 in sciatic nerve and neural cell bodies by loss of Ranbp2. Post-transcriptional deregulation of hnRNPH3 in.

Impaired ECM protein synthesis in infarcted area of S100a4cre+/− × Fstl1flox/flox mice Impaired ECM protein synthesis in infarcted area of S100a4cre+/−

Yuwei Jiang, Daniel C. Berry, Wei Tang, Jonathan M. Graff Cell Reports

Volume 10, Issue 1, Pages (July 2009)

Wound Healing Is Defective in Mice Lacking Tetraspanin CD151

Increased Severity of Bleomycin-Induced Skin Fibrosis in Mice with Leukocyte-Specific Protein 1 Deficiency JianFei Wang, Haiyan Jiao, Tara L. Stewart,

Blockade of EDN3/EDNRB signaling impairs GSC self-renewal, cell migration, and tumorigenic capacity. Blockade of EDN3/EDNRB signaling impairs GSC self-renewal,

Ultraviolet B-Induced Skin Angiogenesis Is Associated with a Switch in the Balance of Vascular Endothelial Growth Factor and Thrombospondin-1 Expression

Effectively regenerating livers transiently accumulate proliferative IGF2BP3-positive cells. Effectively regenerating livers transiently accumulate proliferative.

Jun Asai, Hideya Takenaka, Norito Katoh, Saburo Kishimoto

Deep vein thrombosis resolution is impaired in diet-induced type 2 diabetic mice Fatiha Bouzeghrane, PhD, Xiaochun Zhang, MD, BSc, Guylaine Gevry, BSc,

Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase Kiichiro Yano, Michael.

Fig. 6 Knockdown of nestin impaired tendon repair and regeneration in a rat model of patellar tendon defect. Knockdown of nestin impaired tendon repair.

Representative illustrations of a sagittal lung section stained with H&E in a control and a CS-exposed mouse after 6 months. Representative illustrations.

Differential Cre-ERT activity and PTEN deletion in endometrial epithelial and stromal compartments. Differential Cre-ERT activity and PTEN deletion in.

A subset of Trp53CKO fiber cells fail to exit the cell cycle, but express fiber-cell-specific markers. A subset of Trp53CKO fiber cells fail to exit the.

Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload.

Embryonic corneal defects in E18.5 AP-2β NCC KO mutant embryos.

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Effect of OLHHA on the protein expression of relevant enzymes and factors related to lipid metabolism in the liver of obese Zucker rats. Effect of OLHHA.

Fig. 4. Increased adipocyte differentiation in Cbx7-KO ES cells

Ectopic sprouting and proliferation in Rbpj veins.

Challenge with oxazolone results in epithelial hyperplasia and influx of inflammatory cells into the epidermis and dermis and keratosis as observed in.

Obesity affected the metabolic response to stroke.

Expression data confirm and extend existing knowledge

Effects of doxorubicin and epirubicin on proliferation and apoptosis in the hyperplastic livers of transgenic zebrafish larvae. Effects of doxorubicin.

Effects of ICER deficiency on MB-cAMP-induced activation of PKA-CREB-VEGF signaling and angiogenesis. Effects of ICER deficiency on MB-cAMP-induced activation.

Tamoxifen injections induce DNA damage response signaling in αMHC-MerCreMer mice.αMHC-MerCreMer+/+ mice received an injection of 60 μg/g body weight of.

Detection of nuclear foci by FISH on frozen sections of diaphragm muscle prepared from 2-month-old DMSXL mice. Detection of nuclear foci by FISH on frozen.

Distribution and extent of expression.

Altered HIF-1α dynamics contribute to reduced VEGF expression in diabetic SIECs. (Aa–c) Total cell contents of HIF-1α, pAkt (at residue S473) and pS6 (at.

Chronic phenytoin increases activity levels in Mecp2Null/Y mice.

2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft. 2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft.

Rgs16::GFP expression in pancreatic neoplasia.

Ang-1, ESE-1 and Tie-2 expression levels during teratogen-induced CDH

Impaired elastogenesis in Ltbp4S−/−;Fibulin-4R/R mice with reduced interaction of Ltbp-4L and fibulin-4. Impaired elastogenesis in Ltbp4S−/−;Fibulin-4R/R.

Model of the Ang-1 pathway in early lung development.

Homozygous col22a1−/− embryos show increased percentage of hemorrhages when raised at increased temperature. Homozygous col22a1−/− embryos show increased.

Human and mouse islets express MCH and MCHR1.

Cavitary lesions in C3HeB/FeJ mice.

MMP-9 expression. MMP-9 expression. (A) Lungs from M. tuberculosis-infected (H37Rv, 14 wpi, untreated) and age-matched uninfected (control) mice were harvested.

Effects of Chd1-knockdown on Hmgpi and Klf5 expression

Association of MMP expression with macrophages.

Chd1 expression and CHD1 localization during mouse preimplantation development. Chd1 expression and CHD1 localization during mouse preimplantation development.

c-Met overexpression promotes cell rounding.

Effects of Chd1-knockdown on global gene expression.

Vessel density is decreased in tumors grown in Fbln5−/− mice.

HFHC/STZ guinea pigs develop insulin-independent diabetes that is responsive to oral antihyperglycemic therapy. HFHC/STZ guinea pigs develop insulin-independent.

Oxidative stress is elevated in tumors grown in Fbln5−/− mice.

Histone crotonylation in kidney tubular cells.

Proliferative and morphological defects following TbCALM and TbEpsinR depletion. Proliferative and morphological defects following TbCALM and TbEpsinR.

BCL-3 regulates expression of stemness-associated Wnt targets.

Lack of Ctip2 is associated with impaired proliferation and delayed onset of differentiation during early stages of epidermal development. Lack of Ctip2.

The Angiogenesis Inhibitor Vasostatin does not Impair Wound Healing at Tumor- Inhibiting Doses Bernhard Lange-Asschenfeldt, Paula Velasco, Michael Streit,

Upon challenge with oxazolone, human leukocytes (mainly consisting of T cells) infiltrate the dermis and epidermis. Upon challenge with oxazolone, human.

Volume 69, Issue 11, Pages (June 2006)

Marrow stromal cells for cellular cardiomyoplasty: Feasibility and potential clinical advantages Jih-Shiuan Wang, MDa,b, Dominique Shum-Tim, MDa, Jacques.

Fibroblast activation in WT and NFATc2-deficient mice.

Presentation transcript:

Diabetes-induced impairment in angiogenic capacity in subcutaneous sponge implants. Diabetes-induced impairment in angiogenic capacity in subcutaneous sponge implants. Sterile sponge discs were implanted subcutaneously into control and GK diabetic rats that had been anesthetized with ketamine and xylazine. Sponges were retrieved 10–12 days post-implantation, bisected and either embedded and sectioned or frozen in liquid nitrogen and used for microscopic or biochemical analysis of angiogenic capacity. (A) Representative photomicrographs of hematoxylin-eosin-stained sponge sections revealing fibrovascular invasion. Arrows denote the presence of large and small blood vessels. (B) Representative photomicrographs of CD31 immunofluorescence staining. (C) Quantitation of CD31 fluorescence intensity from images shown in B. (D) Hemoglobin content in the sponges, as determined by using the Drabkin reagent. (E) A proliferation response in sponge implants was assessed by immunostaining for BrdU. (F) Picrosirius-Red-stained sponge sections were viewed under a polarized-light microscope and revealed the presence of red tightly packed mature collagen fibers in sponges from control mice, but these were present to a much lesser extent in sponges from diabetic mice. (G) Collagen type 1 mRNA content from sponges, as assessed by qRT-PCR analyses. ‘C’, control; ‘D’, diabetic. Results are expressed as means±s.e.m. from three independent experiments. *Significantly different from corresponding control values at P≤0.05. Milad S. Bitar, and Fahd Al-Mulla Dis. Model. Mech. 2015;8:65-80 © 2015. Published by The Company of Biologists Ltd