AhR activation alters gene expression in human monocyte-derived DCs

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AhR activation alters gene expression in human monocyte-derived DCs AhR activation alters gene expression in human monocyte-derived DCs. Immature human monocyte-derived DCs were cultured in the presence of DMSO (V) or 10 nM TCDD (T) and exposed to IAV for 24 h. AhR activation alters gene expression in human monocyte-derived DCs. Immature human monocyte-derived DCs were cultured in the presence of DMSO (V) or 10 nM TCDD (T) and exposed to IAV for 24 h. RNA was isolated 24 h postinfection, and qRT-PCR was performed to quantify gene expression of (A) Cyp1a1, (B) Ido1, (C) Ccl17, and (D) Cd209a. Lines connect vehicle- and TCDD-treated samples from same donor pool. Presumptive AHREs were mapped to the (E) Ccl17 and (F) Cd209a upstream regulatory region, and TF binding sites proximal (within 20 bp) to at least two different AHRE were identified using PROMO software. NF-κB family member binding sites, regardless of AHRE proximity are shown. For (A)–(D), a total of four to five donor pools were used per experiment. Anthony M. Franchini et al. ImmunoHorizons 2019;3:219-235 Copyright © 2019 The Authors