Hypermethylation of the miR-145 Promoter Is the Key Regulator of NLRP3 Inflammasome Activation and Plaque Formation Inflammation-induced DNMT1 elevation.

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Hypermethylation of the miR-145 Promoter Is the Key Regulator of NLRP3 Inflammasome Activation and Plaque Formation Inflammation-induced DNMT1 elevation or Tet2 reduction in vascular smooth muscle cells (VSMCs) of the aortic wall, which led to miR-145 promoter hypermethylation and its low expression. Low levels of miR-145 weakened the inhibitory effect of miR-145 on the CD137/NFATc1 axis, which further activated the NLRP3 inflammasome to amplify the inflammatory reaction and induce plaque formation or rupture. Abbreviations as in Figures 3, 5, and 7. Wei Zhong et al. BTS 2018;3:604-624 2018 The Authors