Factors Affecting CB Stability: IO

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Presentation transcript:

Factors Affecting CB Stability: IO Section 3.4

3.4 Qualifying Acidity ARIO - Induction can also stabilize a formal negative charge by spreading it out. How is induction different from resonance? Compare the acidity of the two compounds below by comparing the stabilities of their conjugate bases. How does induction play a role? Copyright © 2015 John Wiley & Sons, Inc. All rights reserved. Klein, Organic Chemistry 2e

3.4 Qualifying Acidity Explain the pKa differences below Practice with SkillBuilder 3.7 Copyright © 2015 John Wiley & Sons, Inc. All rights reserved. Klein, Organic Chemistry 2e

3.4 Qualifying Acidity ARIO - The type of orbital also can affect the stability of a formal negative charge Is a negative charge more stable or less stable if it is held closely to an atom’s nucleus? WHY? Rank the ability of these orbitals (2s, 2p, sp3, sp2, and sp) to stabilize electrons, and explain. Copyright © 2015 John Wiley & Sons, Inc. All rights reserved. Klein, Organic Chemistry 2e

3.4 Qualifying Acidity Compare the acidity of the compounds below by comparing the stabilities of their conjugate bases. How does the type of orbital play a role? Explain the pKa differences above Practice with SkillBuilder 3.8 Copyright © 2015 John Wiley & Sons, Inc. All rights reserved. Klein, Organic Chemistry 2e

3.4 Qualifying Acidity When assessing the acidity of protons, we generally use ARIO as our order of priority The type of atom that carries the charge Resonance Induction The type of orbital where the charge resides Compare ethanol and propylene. Which has a more stable conjugate base? WHY? pKa = 16 pKa = 43 Copyright © 2015 John Wiley & Sons, Inc. All rights reserved. Klein, Organic Chemistry 2e