N. Maril, R. Margalit, S. Rosen, S.N. Heyman, H. Degani

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Detection of evolving acute tubular necrosis with renal 23Na MRI: Studies in rats N. Maril, R. Margalit, S. Rosen, S.N. Heyman, H. Degani Kidney International Volume 69, Issue 4, Pages 765-768 (February 2006) DOI: 10.1038/sj.ki.5000152 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Histopathology of an outer medullary section of an ATN kidney. The kidneys were fixed with 1.25% glutaraldehyde solution 6 h after the insult, and stained with 1% methylene blue. Focal mTAL injury (*) can be seen at high magnification (× 400) adjacent to collecting ducts (CD) and away from the vasa recta (VR). Tubular injury was basically limited to 4% of mTALs in the mid-inner stripe. Kidney International 2006 69, 765-768DOI: (10.1038/sj.ki.5000152) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 Renal sodium distribution under conditions of ATN. Sodium images of rat kidneys recorded 6 h after (a) sham injection and (b) composite injections of indomethacin, Nω-nitro-L-arginine methyl ester, and iothalamate as described in Materials and Methods. Images were recorded using a 3D gradient echo sequence with a TE/TR of 1.7/60 ms, spatial resolution of 0.94 × 0.94 × 5 mm3, and 20 min scanning time. (c, d) The sodium content, relative to that in the cortex, along the corticomedullary axis (marked with a black line on the images) versus the distance from the cortex outer edge. Kidney International 2006 69, 765-768DOI: (10.1038/sj.ki.5000152) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 3 Correlation between the cortico-outer medullary (Cor-OM) sodium gradient and plasma creatinine. The gradients of sham-controlled (○) and ATN (▪) kidneys were calculated from the sodium images, using pixel-by-pixel analysis, as shown in Figure 2. The plasma creatinine was measured immediately after the MRI experiment. Kidney International 2006 69, 765-768DOI: (10.1038/sj.ki.5000152) Copyright © 2006 International Society of Nephrology Terms and Conditions