Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations Gary M. Hunninghake, MD, MPH, Manuel E. Soto-Quirós,

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Presentation transcript:

Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations Gary M. Hunninghake, MD, MPH, Manuel E. Soto-Quirós, MD, PhD, Jessica Lasky-Su, ScD, Lydiana Avila, MD, Ngoc P. Ly, MD, MPH, Catherine Liang, MPH, Barbara J. Klanderman, PhD, Benjamin A. Raby, MD, MPH, Diane R. Gold, MD, MPH, Scott T. Weiss, MD, MS, Juan C. Celedón, MD, DrPH Journal of Allergy and Clinical Immunology Volume 122, Issue 1, Pages 93-98.e5 (July 2008) DOI: 10.1016/j.jaci.2008.03.015 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Pairwise (r2) LD for IL10 in Costa Rican and white (non-Hispanic) CAMP parents. ∗MAF. Journal of Allergy and Clinical Immunology 2008 122, 93-98.e5DOI: (10.1016/j.jaci.2008.03.015) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Regression lines by genotype for SNPs rs1800896 (A), rs3024492 (B), and rs3024496 (C) comparing the specific IgE response to Der p 1 antigen by measured Der p 1 antigen level. Yellow, Homozygotes for the major allele; blue, heterozygotes; red, homozygotes for the minor allele. Journal of Allergy and Clinical Immunology 2008 122, 93-98.e5DOI: (10.1016/j.jaci.2008.03.015) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions