Topical cyclosporine prevents seasonal recurrences of vernal keratoconjunctivitis in a randomized, double-masked, controlled 2-year study Alessandro.

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Presentation transcript:

Topical cyclosporine prevents seasonal recurrences of vernal keratoconjunctivitis in a randomized, double-masked, controlled 2-year study Alessandro Lambiase, MD, PhD, Andrea Leonardi, MD, Marta Sacchetti, MD, PhD, Velika Deligianni, MD, Sabrina Sposato, MD, PhD, Stefano Bonini, MD Journal of Allergy and Clinical Immunology Volume 128, Issue 4, Pages 896-897.e9 (October 2011) DOI: 10.1016/j.jaci.2011.07.004 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Study design. AE, Adverse event; CsA, cyclosporine. Journal of Allergy and Clinical Immunology 2011 128, 896-897.e9DOI: (10.1016/j.jaci.2011.07.004) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 The number of recurrences was significantly reduced when patients were treated with 0.05% cyclosporine with respect to 0.025% ketotifen (A). The cyclosporine group had significantly longer periods free of recurrences compared with the ketotifen group (B). Patients treated with ketotifen had a higher risk of recurrences after a flare-up episode than patients treated with cyclosporine (C). CsA, Cyclosporine; Ket, ketotifen. Journal of Allergy and Clinical Immunology 2011 128, 896-897.e9DOI: (10.1016/j.jaci.2011.07.004) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Itching, photophobia, and conjunctival hyperemia scores showed significant amelioration in patients treated with 0.05% cyclosporine eye drops compared with those seen in patients treated with 0.025% ketotifen eye drops. Data are expressed as means ± SEMs. CsA, Cyclosporine; Ket, ketotifen. Journal of Allergy and Clinical Immunology 2011 128, 896-897.e9DOI: (10.1016/j.jaci.2011.07.004) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Forty-eight recurrences of ocular inflammation were randomized to receive either 0.1% cyclosporine eye drops or 0.15% dexamethasone eye drop 4 times daily for 7 days. A significantly higher number of recurrences treated with 0.1% cyclosporine eye drops (n = 16) required rescue medication after 7 days of treatment compared with recurrences treated with dexamethasone eye drops (n = 7). Journal of Allergy and Clinical Immunology 2011 128, 896-897.e9DOI: (10.1016/j.jaci.2011.07.004) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions