Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity Joanne E. Sordillo, ScD, MS, Roxanne.

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Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity Joanne E. Sordillo, ScD, MS, Roxanne Kelly, BS, MBA, Supinda Bunyavanich, MD, MPH, Michael McGeachie, PhD, Weiliang Qiu, PhD, Damien C. Croteau-Chonka, PhD, Manuel Soto-Quiros, MD, PhD, Lydiana Avila, MD, Juan C. Celedón, MD, DrPH, John M. Brehm, MD, MPH, Scott T. Weiss, MD, MS, Diane R. Gold, MD, MPH, Augusto A. Litonjua, MD, MPH Journal of Allergy and Clinical Immunology Volume 136, Issue 4, Pages 885-892.e2 (October 2015) DOI: 10.1016/j.jaci.2015.02.035 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Effect of dust mite exposure on asthma severity by IL9 SNP genotype (CAMP study). ER, Emergency department. Journal of Allergy and Clinical Immunology 2015 136, 885-892.e2DOI: (10.1016/j.jaci.2015.02.035) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Effect of dust mite exposure on asthma severity by IL9 SNP genotype (GACRS). Journal of Allergy and Clinical Immunology 2015 136, 885-892.e2DOI: (10.1016/j.jaci.2015.02.035) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 A, ORs for increased severe asthma exacerbations (≥1 in the past year) in response to increased dust mite allergen exposure (≥10 μg/g) for subjects without an IL9 polymorphism (rs2069885 wild-type). B, ORs for increased severe asthma exacerbations (≥1 in the past year) in response to increased dust mite allergen exposure (≥10 μg/g) for subjects with an IL9 polymorphism (rs2069885). Journal of Allergy and Clinical Immunology 2015 136, 885-892.e2DOI: (10.1016/j.jaci.2015.02.035) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions