Salt sensitivity in genetically hypertensive rats of the Lyon strain

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Salt sensitivity in genetically hypertensive rats of the Lyon strain Marine Florin, Ming Lo, Kiao Ling Liu, Jean Sassard Kidney International Volume 59, Issue 5, Pages 1865-1872 (May 2001) DOI: 10.1046/j.1523-1755.2001.0590051865.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Indirect systolic blood pressure (SBP) during normal and high salt intake in (A) untreated and (B) perindopril-treated (3 mg/kg/24 h) Lyon hypertensive (LH; squares), Lyon normotensive (LN; triangles), and Lyon low blood pressure (LL; circles) rats. *P < 0.05 LH vs. LN and LL rats. Kidney International 2001 59, 1865-1872DOI: (10.1046/j.1523-1755.2001.0590051865.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Mean blood pressure (MBP), heart rate (HR), urinary sodium (UNaV), and protein excretions during normal and high salt intake in (A) untreated and (B) perindopril-treated (3 mg/kg/24 h) LH (squares) and LL (circles) rats.N = 8 in the LH and N = 6 in the LL untreated groups; N = 7 in the LH and N = 6 in the LL treated groups. *P < 0.05 LH vs. LL rats. Kidney International 2001 59, 1865-1872DOI: (10.1046/j.1523-1755.2001.0590051865.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Individual relationships between 24-hour mean blood pressure (MBP) and 24-hour urinary sodium excretion (UNaV) in untreated (A; ○) LL and (B; □) LH rats. Kidney International 2001 59, 1865-1872DOI: (10.1046/j.1523-1755.2001.0590051865.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 4 Individual relationships between 24-hour mean blood pressure (MBP) and 24-hour urinary sodium excretion (UNaV) in perindopril-treated (A; •) LL and (B; ▪) LH rats. Kidney International 2001 59, 1865-1872DOI: (10.1046/j.1523-1755.2001.0590051865.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 5 Mean blood pressure (MBP), sodium, and water balance before and during chronic aldosterone administration in (A) untreated and (B) valsartan-treated (15 mg/kg/24 h) LH (squares) and LL (circles) rats. *P < 0.05 LH vs. LL rats; N = 6 in the untreated groups and N = 7 in the treated groups. Kidney International 2001 59, 1865-1872DOI: (10.1046/j.1523-1755.2001.0590051865.x) Copyright © 2001 International Society of Nephrology Terms and Conditions