Tandem inversion duplications and their modification.

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Tandem inversion duplications and their modification. Tandem inversion duplications and their modification. Amplifications of this type were recovered in bacteria and yeast after prolonged growth under selection for additional gene copies (Araya et al. 2010; Kugelberg et al. 2010) and are also found in certain cancer cells, especially following exposure to cancer chemotherapy. Their formation is thought to be initiated by short quasi-palindromic structures. (A) One model for TID formation that relies on initiating repair replication at snap-back structures and switching templates to produce symmetrical triplications whose junctions have extended complementary palindromic sequences. (B) Deletions that modify a sTID to generate asymmetric junctions or simple tandem duplications. Andrew B. Reams et al. Genetics 2012;192:397-415 Copyright © 2012 by the Genetics Society of America