Altered in vitro immune response to hypoxia-treated normal peritoneal fibroblasts  Zeynep Alpay, M.D., Melike Özgönenel, M.D., Süreyya Savaşan, M.D., Steven Buck, M.S., Ghassan M. Saed, Ph.D., Michael P. Diamond, M.D.  Fertility and Sterility  Volume 87, Issue 2, Pages 426-429 (February 2007) DOI: 10.1016/j.fertnstert.2006.07.1495 Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 (A) The effect of hypoxia treatment in LAK cell–mediated elimination of NPF and ATF in vitro. As has been shown by our group earlier, LAK cell–mediated cytotoxicity against ATF is superior compared with NPF. Hypoxia treatment increased LAK cell–mediated NPF cytotoxicity closer to ATF levels with a limited effect on ATF itself. Bold horizontal lines denote median values, the top and bottom borders of the boxes denote 75th and 25th percentile values of average satisfaction, namely interquartile range (IQR), and whiskers denote the last data values that lie within 1.5 IQRs. (B) Postoperative adhesion development. This schema summarizes the proposed role of hypoxia on fibroblasts leading to adhesion development, if natural immune system control over the process is not sufficient. Alpay. Anti-fibroblast response in hypoxia. Fertil Steril 2007. Fertility and Sterility 2007 87, 426-429DOI: (10.1016/j.fertnstert.2006.07.1495) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions