Sputum inflammatory cells from patients with allergic rhinitis and asthma have decreased inflammasome gene expression Willie June Brickey, PhD, Neil.

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Sputum inflammatory cells from patients with allergic rhinitis and asthma have decreased inflammasome gene expression Willie June Brickey, PhD, Neil E. Alexis, PhD, Michelle L. Hernandez, MD, William Reed, PhD, Jenny P.Y. Ting, PhD, David B. Peden, MD Journal of Allergy and Clinical Immunology Volume 128, Issue 4, Pages 900-903 (October 2011) DOI: 10.1016/j.jaci.2011.08.012 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Assessment of innate immune factors in sputum airway cells. A, Sputum supernatant protein levels for healthy volunteers and asthmatic patients are analyzed by means of multiplex ELISA, with mean levels indicated by bars. B and C, Gene expression is assessed by means of oligonucleotide microarray hybridization (Fig 1, B) and PCR (Fig 1, C). Mean normalized microarray signal intensity ratios of experimental to universal reference RNA ± SEM in healthy volunteers, asthmatic patients, and patients with AR are plotted (n = 8-10 per group). Mean PCR-amplified transcripts relative to ACTB ± SEM are plotted (n = 5 per group). Statistical tests include unpaired t tests (Fig 1, A) and 1-way ANOVA (Fig 1, B and C) for 3 groups (with overall P values depicted over the line) with the Dunnett multiple comparison test for healthy volunteers (with P values indicated as follows: ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001). AR, Patients with AR; Asth, asthmatic patients; NV, healthy volunteers. Journal of Allergy and Clinical Immunology 2011 128, 900-903DOI: (10.1016/j.jaci.2011.08.012) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions