The role of atopic sensitization in flexural eczema: Findings from the International Study of Asthma and Allergies in Childhood Phase Two Carsten Flohr,

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Presentation transcript:

The role of atopic sensitization in flexural eczema: Findings from the International Study of Asthma and Allergies in Childhood Phase Two Carsten Flohr, MRCPCH, Stephan K. Weiland, MD, Gudrun Weinmayr, PhD, Bengt Björkstén, PhD, Lennart Bråbäck, PhD, Bert Brunekreef, PhD, Gisela Büchele, MPH, Michael Clausen, MD, William O.C. Cookson, PhD, Erika von Mutius, MD, David P. Strachan, MD, Hywel C. Williams, PhD Journal of Allergy and Clinical Immunology Volume 121, Issue 1, Pages 141-147.e4 (January 2008) DOI: 10.1016/j.jaci.2007.08.066 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Proportion of atopy among children with flexural eczema for all study centers. Study centers are arranged in order of proportion of atopy separately for affluent (red) and nonaffluent (blue) countries. Journal of Allergy and Clinical Immunology 2008 121, 141-147.e4DOI: (10.1016/j.jaci.2007.08.066) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Forest plot of age- and sex-adjusted ORs for atopy (exposure) and flexural eczema (outcome) for each study center (red, affluent countries; blue, nonaffluent countries). Within each group, centers are arranged in order of GNI. Journal of Allergy and Clinical Immunology 2008 121, 141-147.e4DOI: (10.1016/j.jaci.2007.08.066) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 PAFs for all study centers (red, affluent countries; blue, nonaffluent countries). Study centers are arranged in order of magnitude of PAF. Journal of Allergy and Clinical Immunology 2008 121, 141-147.e4DOI: (10.1016/j.jaci.2007.08.066) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 ORs for the association of atopy with flexural eczema plotted against GNI. Journal of Allergy and Clinical Immunology 2008 121, 141-147.e4DOI: (10.1016/j.jaci.2007.08.066) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Flexural eczema prevalences with 95% CIs for all study centers Flexural eczema prevalences with 95% CIs for all study centers. Study centers are arranged in order of flexural eczema prevalence, separately for affluent (red) and nonaffluent (blue) countries. Journal of Allergy and Clinical Immunology 2008 121, 141-147.e4DOI: (10.1016/j.jaci.2007.08.066) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Atopy prevalences with 95% CIs for all study centers are arranged in order of atopy prevalence, separately for affluent (red) and nonaffluent (blue) countries. Journal of Allergy and Clinical Immunology 2008 121, 141-147.e4DOI: (10.1016/j.jaci.2007.08.066) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fraction (%) of flexural eczema attributable to skin test reactivity (PAF) plotted against GNI. Journal of Allergy and Clinical Immunology 2008 121, 141-147.e4DOI: (10.1016/j.jaci.2007.08.066) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions