On the Regulation of Hair Keratin Expression: Lessons from Studies in Pilomatricomas Bernard Cribier, Bernard Peltre, Edouard Grosshans, Lutz Langbein,

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On the Regulation of Hair Keratin Expression: Lessons from Studies in Pilomatricomas Bernard Cribier, Bernard Peltre, Edouard Grosshans, Lutz Langbein, Jürgen Schweizer Journal of Investigative Dermatology Volume 122, Issue 5, Pages 1078-1083 (May 2004) DOI: 10.1111/j.0022-202X.2004.22513.x Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Expression studies in hair follicles. Normal human scalp sections were reacted with the following antibodies. (A) Ki67, (B) hHa5––note the presence of hHa5 in some cells lining the dermal papilla (arrows) but absence of this keratin in the medulla, (C) hHa1, (D) HOXC13, (E, F) LEF1––note the apparent lack of LEF1 in the medulla of the hair follicle of panel F, (G) β-catenin (Sigma antibody; see Material and Methods), (H) β-catenin (Transduction Laboratories antibody; see Material and Methods), (I) β-catenin, higher magnification of the pre-cortex region in H. Cells exhibiting nuclear β-catenin location are indicated by arrowheads. gc, germinative compartment; ma, matrix; me, medulla; co, cortex; cu, cuticle; pc, pre-cortex; irs, inner root sheath; ors, outer root sheath; dp, dermal papilla. Bars=100 μm (A–F,H); 200 μm (G); 50 μm (I). Journal of Investigative Dermatology 2004 122, 1078-1083DOI: (10.1111/j.0022-202X.2004.22513.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Expression studies in pilomatricomas. Serial sections of a pilomatricoma were reacted with antibodies against (A) Ki67, (B) HOXC13, (C) hHa5, (D) hHa1. bc, basaloid cells, ltc, lower transitional cells; utc, upper transitional cells. Bars=100 μm. Journal of Investigative Dermatology 2004 122, 1078-1083DOI: (10.1111/j.0022-202X.2004.22513.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Expression studies in pilomatricomas. Serial sections of a pilomatricoma were reacted with antibodies against (A) LEF1, (B) HOXC13, (C) β-catenin (Transduction Laboratories antibody). The dotted lines in panels A and B delineate the boundary between basaloid and lower transitional cells. The arrows in C indicate a small band of strongly β-catenin-positive upper transitional cells. Bars=100 μm. Journal of Investigative Dermatology 2004 122, 1078-1083DOI: (10.1111/j.0022-202X.2004.22513.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Expression studies in pilomatricomas. Serial section of a pilomatricoma were reacted with antibodies against (A) Ki67, (B) LEF1, (C) β-catenin (Sigma antibody), (D) hHa1. The small arrows in the inset of panel C denote cells or cell groups expressing nuclear β-catenin. Bars=100 μm. Journal of Investigative Dermatology 2004 122, 1078-1083DOI: (10.1111/j.0022-202X.2004.22513.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions