Retinal nerve fibre layer (RNFL) thickness versus age in patients with WFS (white dots) and in age-matched normal subjects (black dots). Retinal nerve fibre layer (RNFL) thickness versus age in patients with WFS (white dots) and in age-matched normal subjects (black dots). Lines join sequential annual measures of the same patient with WFS. WFS, Wolfram syndrome. James Hoekel et al. BMJ Open Ophth 2018;3:e000081 © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.