(A) Plasma renin activity in Wistar rats, SHRs, and DOCA-salt rats, n = 8 to 9/group; data are presented as mean ± S.E.M. Dose-response relationship on.

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(A) Plasma renin activity in Wistar rats, SHRs, and DOCA-salt rats, n = 8 to 9/group; data are presented as mean ± S.E.M. Dose-response relationship on maximal mean arterial blood pressure decrease after single oral administration of aprocitentan (0.3–300 mg/kg, n = 4–11/group) (B) and valsartan (0.3–100 mg/kg, n = 6–24/group) (C) in conscious SHRs (left) and DOCA-salt rats (right) equipped with telemetry. (A) Plasma renin activity in Wistar rats, SHRs, and DOCA-salt rats, n = 8 to 9/group; data are presented as mean ± S.E.M. Dose-response relationship on maximal mean arterial blood pressure decrease after single oral administration of aprocitentan (0.3–300 mg/kg, n = 4–11/group) (B) and valsartan (0.3–100 mg/kg, n = 6–24/group) (C) in conscious SHRs (left) and DOCA-salt rats (right) equipped with telemetry. Data are presented as mean ± S.E.M. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 compared with vehicle-treated rats. Frederic Trensz et al. J Pharmacol Exp Ther 2019;368:462-473 Copyright © 2019 The Author(s).