Asthma control can be maintained when fluticasone propionate/salmeterol in a single inhaler is stepped down  Eric D. Bateman, MD, Loretta Jacques, PhD,

Slides:



Advertisements
Similar presentations
Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,
Advertisements

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,
Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial Saifudin.
Defective B-cell memory in patients with Down syndrome Ruud H.J. Verstegen, MD, Gertjan J. Driessen, MD, Sophinus J.W. Bartol, BSc, Carel J.M. van Noesel,
Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.
D-dimer: A biomarker for antihistamine-resistant chronic urticaria
Comparison of adjustable- and fixed-dose budesonide/formoterol pressurized metered- dose inhaler and fixed-dose fluticasone propionate/salmeterol dry powder.
The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5- year follow-up: Effectiveness of early intervention with budesonide in.
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Allergen immunotherapy: A practice parameter third update
Treating acute rhinosinusitis: Comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo  Eli O. Meltzer, MD, Claus Bachert,
High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE  Elizabeth A. Erwin,
Fatty acids, inflammation, and asthma
The XTEND-CIU study: Long-term use of omalizumab in chronic idiopathic urticaria  Marcus Maurer, MD, Allen Kaplan, MD, Karin Rosén, MD, PhD, Michael Holden,
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Fluticasone furoate nasal spray: A single treatment option for the symptoms of seasonal allergic rhinitis  Harold B. Kaiser, MD, Robert M. Naclerio, MD,
Exposure of infants to budesonide through breast milk of asthmatic mothers  Anette Fält, BSc, Thomas Bengtsson, MSc, Britt-Marie Kennedy, BSc, Ann Gyllenberg,
Is 9 more than 2 also in allergic airway inflammation?
Desensitization to Chemotherapeutic Agents
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Fatty acids, inflammation, and asthma
Hospitalization rates and prognosis of patients with anaphylactic shock in Denmark from 1995 through 2012  Anni Nørgaard Jeppesen, MD, Christian Fynbo.
Rising prevalence of asthma is sex-specific in a US farming population
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16- Arg/Arg patients with asthma  Eric D. Bateman, MD, Oliver Kornmann,
Nonadherence to Asthma Treatment: Getting Unstuck
Peter M. Wolfgram, MD, David B. Allen, MD 
Etiology of asthma exacerbations
Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA 
Reply Journal of Allergy and Clinical Immunology
Phillip Lieberman, MD, Michael Tankersley, MD 
Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation  Leif Bjermer, MD  Journal of Allergy.
Phillip Lieberman, MD, David Golden, MD 
Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management  Scott H. Sicherer, MD, Hugh A. Sampson, MD  Journal.
Biosimilars and drug development in allergic and immunologic diseases
A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity  Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,
Claus Bachert, MD, PhD, Cezmi A. Akdis, MD 
Effect of ingested H1 antihistamines on methacholine challenge
News Beyond Our Pages Journal of Allergy and Clinical Immunology
What is an “eosinophilic phenotype” of asthma?
Onset of action of pimecrolimus cream 1% in the treatment of atopic eczema in infants  Roland Kaufmann, MD, Regina Fölster-Holst, MD, Peter Höger, MD,
Treating acute rhinosinusitis: Comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo  Eli O. Meltzer, MD, Claus Bachert,
H. William Kelly, PharmD  Journal of Allergy and Clinical Immunology 
Autophagy: Nobel Prize 2016 and allergy and asthma research
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment
Advances in the approach to the patient with food allergy
Comparison of adjustable- and fixed-dose budesonide/formoterol pressurized metered- dose inhaler and fixed-dose fluticasone propionate/salmeterol dry powder.
Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L
Bruce G. Bender, PhD, Alex Pedan, PhD, Laleh T. Varasteh, RPh, MSF 
Exposure of infants to budesonide through breast milk of asthmatic mothers  Anette Fält, BSc, Thomas Bengtsson, MSc, Britt-Marie Kennedy, BSc, Ann Gyllenberg,
Risk of oral food challenges
Benjamin Chaigne, MD, Hervé Watier, MD, PhD 
Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen- induced asthmatic reactions  Emmerentia van Schalkwyk, MBChB, K. Strydom,
Acid-suppressive drug use in pregnancy and the toddler's asthma risk: A crossover, case-control study  Bianca Mulder, BSc, Catharina Carolina Maria Schuiling-Veninga,
Pınar Uysal, MD, Esben Eller, MSc, PhD, Charlotte G
Measles and immunomodulation
Short course of systemic corticosteroids in sinonasal polyposis: A double-blind, randomized, placebo-controlled trial with evaluation of outcome measures 
Macrolide antibiotics and asthma treatment
Neil W. Johnston, MSc, Sebastian L. Johnston, MD, PhD, Joanne M
Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge  Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.
Asthma: The past, future, environment, and costs
Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16- Arg/Arg patients with asthma  Eric D. Bateman, MD, Oliver Kornmann,
Environmental factors and eosinophilic esophagitis
The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy  Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.
Advances in pediatric asthma in 2007
Confirmation and improvement of criteria for clinical phenotyping in common variable immunodeficiency disorders in replicate cohorts  Helen Chapel, MA,
Natural history of cow’s milk allergy
Primary prevention of asthma and allergy
News Beyond Our Pages Journal of Allergy and Clinical Immunology
Presentation transcript:

Asthma control can be maintained when fluticasone propionate/salmeterol in a single inhaler is stepped down  Eric D. Bateman, MD, Loretta Jacques, PhD, Caroline Goldfrad, MSc, Tito Atienza, MD, Triaian Mihaescu, MD, Marie Duggan, BSc  Journal of Allergy and Clinical Immunology  Volume 117, Issue 3, Pages 563-570 (March 2006) DOI: 10.1016/j.jaci.2005.11.036 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Study design. Patients were considered eligible for randomization if they fulfilled the criteria for well controlled asthma during each of the last 4 weeks of the open-label period. prn, As needed; b.i.d., twice daily. Journal of Allergy and Clinical Immunology 2006 117, 563-570DOI: (10.1016/j.jaci.2005.11.036) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Flow of patients in study. Journal of Allergy and Clinical Immunology 2006 117, 563-570DOI: (10.1016/j.jaci.2005.11.036) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Percentage of subjects achieving asthma control during each week of the study (ITT population). A, Well controlled asthma. B, Total control of asthma. Only patients who were randomized to double-blind treatment are presented. Includes 53 patients who were randomized even though they had not achieved well-controlled asthma over weeks 9-12 of the open-label phase. bid, Twice daily. Journal of Allergy and Clinical Immunology 2006 117, 563-570DOI: (10.1016/j.jaci.2005.11.036) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions