Topical application of dehydroxymethylepoxyquinomicin improves allergic inflammation via NF-κB inhibition Asuka Hamasaka, MD, PhD, Naoya Yoshioka, MS,

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Presentation transcript:

Topical application of dehydroxymethylepoxyquinomicin improves allergic inflammation via NF-κB inhibition Asuka Hamasaka, MD, PhD, Naoya Yoshioka, MS, Riichiro Abe, MD, PhD, Satoshi Kishino, PhD, Kazuo Umezawa, MD, PhD, Michitaka Ozaki, MD, PhD, Satoru Todo, MD, PhD, Hiroshi Shimizu, MD, PhD Journal of Allergy and Clinical Immunology Volume 126, Issue 2, Pages 400-403 (August 2010) DOI: 10.1016/j.jaci.2010.05.020 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Effect of DHMEQ on contact hypersensitivity response. A, DHMEQ effectively inhibited the NF-κB activity in macrophagelike cell line RAW264.7 with LPS stimulation (10 μg/mL). B, DHMEQ, tacrolimus, or ointment base was applied topically. All ear-swelling values are shown as means ± SEs (n = 5). ∗P < .01; ∗∗P < .005. C, DHMEQ was applied in various concentrations. D, The density of mRNA expression of skin was analyzed by RT-PCR. E, The number of LCs was counted. ∗P < .05 (n = 4 for each group). F, LC morphology in epidermal sheet preparations derived from untreated (left) and DHMEQ-treated (right) mice. Journal of Allergy and Clinical Immunology 2010 126, 400-403DOI: (10.1016/j.jaci.2010.05.020) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Improvement of atopic dermatitis model mice by DHMEQ. NC/Nga mice were applied topically with DHMEQ, tacrolimus, or ointment base. A, Clinical features of each mouse. B, The clinical skin score of each group is given as mean ± SE. ∗P < .005. C, Specimens were collected from the dorsal skin and were stained with hematoxylin and eosin, direct fast scarlet for eosinophils, or toluidine blue for mast cells. Journal of Allergy and Clinical Immunology 2010 126, 400-403DOI: (10.1016/j.jaci.2010.05.020) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions