Association between Q551R IL4R genetic variants and atopic asthma risk demonstrated by meta-analysis  Matthew J. Loza, PhD, Bao-Li Chang, PhD  Journal of Allergy and Clinical Immunology  Volume 120, Issue 3, Pages 578-585 (September 2007) DOI: 10.1016/j.jaci.2007.05.019 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Estimation of the number of subjects needed to detect modest risks. For an assumed genotype frequency of 0.3 and minor allele frequency of 0.16 in the control population, presented are estimations of power versus number of subjects per group needed to detect the indicated ORs of a causal allele at an α significance level of .05, assuming no genotyping errors, missing data, or population heterogeneity. Journal of Allergy and Clinical Immunology 2007 120, 578-585DOI: (10.1016/j.jaci.2007.05.019) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 R551 IL4R variant associated with increased atopic asthma risk. From meta-analyses of data from studies meeting inclusion criteria: A, Forest plots show the OR for asthma risk imparted by the R551 IL4R variant. ∗P = .004 and ∗∗P = .002. B, L'Abbe plots show the G allele and AG + GG genotype frequencies of asthmatic and control subjects for Q551R IL4R variants. Journal of Allergy and Clinical Immunology 2007 120, 578-585DOI: (10.1016/j.jaci.2007.05.019) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Association of I50V IL4R variants with asthma risk. From meta-analyses of data from studies meeting inclusion criteria: A, Forest plots show the OR for asthma risk imparted by the V50 IL4R variant. B, L'Abbe plots show the G allele and AG + GG genotype frequencies of asthmatic and control subjects for I50V IL4R variants. Journal of Allergy and Clinical Immunology 2007 120, 578-585DOI: (10.1016/j.jaci.2007.05.019) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions