A: Total collagen content by Sirius red staining in cardiac tissue of control (SD) animals. A: Total collagen content by Sirius red staining in cardiac.

Slides:

Advertisements

Similar presentations

Temporary Presence of Myofibroblasts in Human Elbow Capsule After Trauma by Job N. Doornberg, Tjalling Bosse, Mark S. Cohen, Jesse B. Jupiter, David Ring,

Advertisements

Lipid hydroperoxide levels (μM) in hepatic tissue lyaste after 1 and 5 h of reperfusion after 60 min of ischemia. Lipid hydroperoxide levels (μM) in hepatic.

Cardiac-Specific Overexpression of HIF-1α Prevents Deterioration of Glycolytic Pathway and Cardiac Remodeling in Streptozotocin-Induced Diabetic Mice

Healing of an Asymptomatic Carotid Plaque Ulceration

Inhibition of ILK by QLT-0267 suppresses type I and type III collagen expression and ameliorates interstitial collagen deposition and renal fibrosis after.

Skovseth et al. Endostatin dramatically inhibits endothelial cell migration, vascular morphogenesis, and perivascular cell recruitment in vivo. Blood.

DNA-damage (γ-H2AX) and telomere damage–induced foci (TIFs).

AAV8‐hAAT‐FGF21 treatment improves liver fibrosis

INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice. INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice.

Metformin decreases mTORC1 activity in the basal layer of oral epithelial dysplasias and mitotic activity in the hyperplastic epithelium. Metformin decreases.

Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),

Romain Gallet et al. BTS 2016;1:14-28

The Relentless Effects of the Fontan Paradox

Isaac Perea-Gil et al. BTS 2016;1:

Cardiac Fibrosis at 18 Weeks Post TAC (A) Representative images (original magnification ×20) of Picrosirius red-stained cardiac tissue sections from HF +

Renal Fibrosis and Plasma Creatinine Levels at 18 Weeks Post TAC (A) Plasma creatinine levels. (B) Representative images (original magnification ×20) of.

LncRNA ZEB1-AS1 Was Suppressed by p53 for Renal Fibrosis in Diabetic Nephropathy Juan Wang, Jian Pang, Huiling Li, Jie Long, Fang Fang, Junxiang Chen,

LXs reverse established DKD. (A) Study design overview.

Collagen accumulation is reduced with UK

Figure 1 CD52 expression on innate myeloid and lymphoid cell subsets

Glycogen concentration in A

Supplementation with vitamins C+E significantly inhibited acellular capillaries in diabetic rats and tended to inhibit formation of pericyte ghosts but.

Lypolytic activity (glycerol release, mg/ml) measured in adipocytes culture medium after 2 h incubation with isoproterenol or 8-Cl-cAMP. Lypolytic activity.

Central nervous system BDNF infusion fails to increase tissue glucose uptake in uncontrolled insulin-deficient diabetes. Central nervous system BDNF infusion.

Decreased P-IR and total FOXO1 levels in an HFS diet.

Cellularity of epididymal adipose tissue.

Reversal of MOR lysosomal targeting by silencing enhanced Rab7 expression. Reversal of MOR lysosomal targeting by silencing enhanced Rab7 expression. A:

BTG2 regulates gluconeogenic gene expression in diabetic mouse models

Regorafenib inhibits angiogenesis and induces apoptosis.

A and B: Total caloric intake in sham rats on chow and in gastroduodenal and hepatic vagotomized rats treated with STZ with access to lard and chow. A.

1018-NT-β-cell clusters protect mice from STZ-induced diabetes.

SIRT1 is downregulated in human gastric cancer (GC).

Sox4 promotes hepatic TG accumulation in vivo.

Expression of VCAM-1 and inflammatory cytokines in injured carotid arteries in STZ-induced diabetic rats. Expression of VCAM-1 and inflammatory cytokines.

Nrf2−/− mice had higher TGF-β1 transcription and FN expression.

PMPs survive STZ cytotoxicity and produce larger colonies with a higher yield of insulin+ progeny. PMPs survive STZ cytotoxicity and produce larger colonies.

Nrf2−/− mice suffered greater renal damage by STZ compared with Nrf2+/+ mice. Nrf2−/− mice suffered greater renal damage by STZ compared with Nrf2+/+ mice.

IL-6 inhibits insulin-induced formation of p85/IRS-1 complexes.

Zn2+ and NAD(P)H content in Mafa∆panc and Mafa∆panc;Mafb+/− β-cells.

Subsarcolemmal (SS) mitochondrial width (A) and density (B) and intermyofibrillar (IMF) mitochondrial density in close proximity of (D) or distant from.

Effect of berberine on white adipose tissue mass.

SW fraction induces S phase arrest and apoptosis.

Muscle LCACoA content in the basal (A) and clamp (B) states.

Baroreflex function measured by the modified Oxford method during baseline euglycemia (circles) and hypoglycemia (triangles). Baroreflex function measured.

Insulitis is reduced in CT-treated RIP-LCMV-GP mice.

Effects of pterosin A on serum levels of lipid, blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), and alanine aminotransferase (ALT)

A: Chemical structure of pterosin A

A1C (A) and serum glycated albumin (GA) (B) levels in 47 pregnant women (study 1) divided according to gestational period into group I (21–24 weeks; n.

Effect of PEDF+DHA treatment on wound healing in diabetic corneas.

Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice.

PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded skin. PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded.

Functional and histological examinations of diabetic EC-PKCβ2Tg and WT mice. Functional and histological examinations of diabetic EC-PKCβ2Tg and WT mice.

Analysis of tumor-infiltrating CD8+ T cells and effect of T and NK cell depletion. Analysis of tumor-infiltrating CD8+ T cells and effect of T and NK cell.

A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R.

A: Brain regions in the PET study where insulin-stimulated GU was measured in carriers and noncarriers of the p.P50T/AKT2 variant. A: Brain regions in.

TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor tissues. TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor.

Type I collagen–targeted PET probe for pulmonary fibrosis detection and staging in preclinical models by Pauline Désogère, Luis F. Tapias, Lida P. Hariri,

A, ATP production by PC3 prostate cancer cells after treatment with oligonucleotide/Lipofectin complexes. a, ATP production by PC3 prostate cancer cells.

Bar graph shows the preventive effect of UV on the development of vasospasm for different irradiation time periods. Bar graph shows the preventive effect.

Tumors treated with anti-Flk-1 mAb have increased tumor cell apoptosis, reduced tumor cell proliferation, and increased tumor necrosis. s.c. Tumors treated.

Lung tumors in KrasLA1 mice are fibrotic.

Ki-67 expression in M31- and H3-treated tumors (A) and respective Ki-67 labeling indices in the two groups of tumors (B). Ki-67 expression in M31- and.

Ablation of Nf1 in HOXB7 lineage cells gives rise to diffuse cNF.

Chronic Treg reduction results in dermal fibrosis.

Effect of CDV on human SF7796 xenografts in vivo.

Chronic Treg reduction exacerbates bleomycin-induced skin fibrosis.

PI3Kγ promotes macrophage PDGF-BB expression to control PDAC fibrosis.

Detection of microcalcifications in 4T1 mammary tumors and human breast tumor tissue. Detection of microcalcifications in 4T1 mammary tumors and human.

Administration of anti-glial cell line-derived neurotrophic factor (anti-GDNF) antibodies reduces liver fibrosis development in mice. Administration of.

Changes of major clinical and biochemical characteristics at baseline and during follow-up in different groups. Changes of major clinical and biochemical.

Presentation transcript:

A: Total collagen content by Sirius red staining in cardiac tissue of control (SD) animals. A: Total collagen content by Sirius red staining in cardiac tissue of control (SD) animals. B: Highly increased total collagen with cardiac and perivascular fibrosis in STZ-induced diabetes. C: Total collagen content of STZ, treated with the ICEI (STZICEI). Bars are displaying total collagen content according to Sirius red staining, as well as collagen type I and collagen type III. *Significantly different compared with control and STZICEI, with P < 0.05. Dirk Westermann et al. Diabetes 2007;56:1834-1841 ©2007 by American Diabetes Association