Promotion of Acyclic Form General Base Catalysis

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Presentation transcript:

Promotion of Acyclic Form General Base Catalysis A Characterization of the Maillard Reaction of Ribose 5-Phosphate and Amino Acids Roger K. Sandwick, Department of Chemistry and Biochemistry, Middlebury College, Middlebury, VT 05753 The goal of our research is to determine why ribose 5-phosphate (R5P) undergoes a Maillard reaction with amines at rates significantly higher than most other sugars and sugar phosphates. It is believed that the intramolecular phosphate group is either responsible for causing a higher level of acyclic form of the ribose sugar or for enhancing the rate of reaction through a general acid/base mechanism. Promotion of Acyclic Form General Base Catalysis Ribose 5-Phosphate The kinetics of the Maillard reaction between R5P and various amino acids is fully characterized and will be compared to the rates of similar reactions with and without intramolecular phosphate and of molecules containing modified (esterified) phosphate moieties. Some novel UV-absorbing compounds have been determined using 2-deoxyribose 5-phosphate analogues to R5P.