Tamoxifen injections in αMHC-MerCreMer mice induce a loxP-independent DNA damage response, leading to myocardial dysfunction and death. Tamoxifen injections.

Slides:

Advertisements

Similar presentations

SESN2 expression in lungs from healthy donors, habitual smokers without COPD and individuals with late-stage COPD. (A) Representative western blots of.

Advertisements

The role of telomerase, telomeres and senescent cells in zebrafish heart regeneration. The role of telomerase, telomeres and senescent cells in zebrafish.

Cellular analysis of Epo transgenic mice.

Representative flow cytometric analysis of bone marrow, spleen and whole blood from EpoWT/WT, EpoΔ/Δ and EpoWT/Δ mice. Representative flow cytometric analysis.

VacA does not induce phosphorylation of Src in RPTPα constitutive-knockdown AZ-521 cells. VacA does not induce phosphorylation of Src in RPTPα constitutive-knockdown.

BTN1 mRNA level in response to extracellular pH determined by comparative RT2PCR. BTN1mRNA level in response to extracellular pH determined by comparative.

Differential Cre-ERT activity and PTEN deletion in endometrial epithelial and stromal compartments. Differential Cre-ERT activity and PTEN deletion in.

Post-ischemic vascular repair mechanisms and the growth factors involved. Post-ischemic vascular repair mechanisms and the growth factors involved. The.

Total and differential cell counting in the broncho-alveolar lavage of mice exposed to CS or air during 3 or 6 months. Total and differential cell counting.

Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload.

Discordance and similarity between humans with FA and FA mouse models.

Molecular profiles of lung, and of blood and plasma in M

Inflammation is associated with increased basal-cell plasticity in the Nkx3.1 mutant prostate. Inflammation is associated with increased basal-cell plasticity.

Crotonate increases histone crotonylation in mouse kidney.

Validation of ddPCR assay for detection of KrasLox-G12D allele using LNA-2 primers. Validation of ddPCR assay for detection of KrasLox-G12D allele using.

TP53 western blot of primary cultured tail cells from both wild-type (WT) and Tp53Δ11/Δ11 (−/−) rats. TP53 western blot of primary cultured tail cells.

Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC. Ingenuity pathway analysis of the genes enriched in both 96-h-induced.

Tomoregulin-1 inhibits the TGFβ non-canonical (TAK1-JNK) pathways after pressure overload. Tomoregulin-1 inhibits the TGFβ non-canonical (TAK1-JNK) pathways.

Hipk induces cell spreading.

Pie charts showing the percentage of genes for selected enriched biological functions and pathways at different time points after hyperthermic seizures.

Challenge with oxazolone results in epithelial hyperplasia and influx of inflammatory cells into the epidermis and dermis and keratosis as observed in.

Characterization of Col1a1FRT-STOP-FRT-Cre-ER-T2 mice.

Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice. Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice.

Working hypothesis of histone lysine crotonylation in kidney injury.

TWEAK downregulates SIRT3 in cultured tubular cells and this is prevented by crotonate. TWEAK downregulates SIRT3 in cultured tubular cells and this is.

Behavioral test parameters.

Obesity affected the metabolic response to stroke.

Formation of papilloma lesions in the UroIICre+Fgfr3+/K644EK-RasG12D/+ model. Formation of papilloma lesions in theUroIICre+Fgfr3+/K644EK-RasG12D/+model.

Proteins associated with PfSec13.

Effects of tumour size on response to treatment in the KPC model.

Expression data confirm and extend existing knowledge

Factors affecting standardization of rodent impact TBI models.

The cellular and molecular differences between acute healing wounds and chronic non-healing wounds. The cellular and molecular differences between acute.

Silencing of Keap1 reduced the expression of inflammatory markers in ConA-injected livers. Silencing of Keap1 reduced the expression of inflammatory markers.

Hipk induces overgrowths in Drosophila imaginal discs.

Transduction with Cre-expressing adenoviruses induces cardiomyocyte apoptosis and shows that transgene insertion is not required. Transduction with Cre-expressing.

Tamoxifen injections induce DNA damage response signaling in αMHC-MerCreMer mice.αMHC-MerCreMer+/+ mice received an injection of 60 μg/g body weight of.

SLE: the many players involved in systemic autoimmunity and tissue destruction. SLE: the many players involved in systemic autoimmunity and tissue destruction.

Elevated expression of vegfaa in hemangiosarcoma.

Cre-loxP-mediated chromosomal engineering in mice.

Distribution and extent of expression.

Comparison ofMyc-induced zebrafish liver tumors with different stages of human HCC and seven mouse HCC models. Comparison ofMyc-induced zebrafish liver.

Functional classification and visualization of differentially expressed genes. Functional classification and visualization of differentially expressed.

The genomic distribution of essential and non-essential mouse genes, separated into known and predicted essentiality. The genomic distribution of essential.

Variations in tissue stiffness.

TWEAK increases histone crotonylation in kidney tubular cells.

Detection of gene recombination in endoxifen- or Adeno-Cre-induced tumours. Detection of gene recombination in endoxifen- or Adeno-Cre-induced tumours.

Cellular reaction to intraventricular DMSO injection.

Chronic phenytoin increases activity levels in Mecp2Null/Y mice.

2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft. 2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft.

Ang-1, ESE-1 and Tie-2 expression levels during teratogen-induced CDH

Expression of transgenic IGF-1Ea propeptide in the skin increases local Treg cell numbers. Expression of transgenic IGF-1Ea propeptide in the skin increases.

Tissue ATP levels measured in the liver, muscle, kidney and pancreas of CDs/y and CDr/y on RD or DD. *P

Increased expression of the drusen-associated genes (ApoE, ApoJ, ApoB and App) and Vegfa in the RPE/retina of Pgc-1α+/− mice under RD and HFD. (A) The.

Tamoxifen injections cause dose-dependent lethal heart failure in αMHC-MerCreMer mice. Tamoxifen injections cause dose-dependent lethal heart failure in.

Effect of Dipy on the expression of chondrogenic markers.

Nerve conduction slowing and DRG sensory neuron and nuclear atrophy in 16-week-old diabetic mice. Nerve conduction slowing and DRG sensory neuron and nuclear.

Expression of transgenic IGF-1Ea propeptide in the skin reduces the severity of contact hypersensitivity responses. Expression of transgenic IGF-1Ea propeptide.

Optimized STZ treatment leads to specific cytotoxicity of insulin-producing cells. Optimized STZ treatment leads to specific cytotoxicity of insulin-producing.

Cross-validation between centres for inbred mice.

Gα12 is not required for hepatic cystogenosis induced by Pkd1 knockout

Therapeutic delivery of rhIGF-1 reduces the severity of contact hypersensitivity responses. Therapeutic delivery of rhIGF-1 reduces the severity of contact.

Pgc-1α+/− mice show an increased inflammatory response to LPS injection. Pgc-1α+/− mice show an increased inflammatory response to LPS injection. (A) RPE/retina.

Systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic sclerosis (SSc) cause immune-mediated.

Cardiac phenotypes in mouse models of systemic lupus erythematosus (SLE). Cardiac phenotypes in mouse models of systemic lupus erythematosus (SLE). We.

Peroxisome speeds were slower in patient and control cells.

Accelerated retinal degeneration after systemic depletion of circulating BM-derived microglia in rd7/rd7;Tg/Tg mice. Accelerated retinal degeneration after.

Effect of siRNA transfection on colony formation by Renca cells.

Functional and molecular regeneration in mdx muscle with matrix treatment. Functional and molecular regeneration in mdx muscle with matrix treatment. (A,B)

Regulation of Bcl-2 family proteins in the hypothalamus of non-diabetic and diabetic IRS2−/− mice. Regulation of Bcl-2 family proteins in the hypothalamus.

Presentation transcript:

Tamoxifen injections in αMHC-MerCreMer mice induce a loxP-independent DNA damage response, leading to myocardial dysfunction and death. Tamoxifen injections in αMHC-MerCreMer mice induce a loxP-independent DNA damage response, leading to myocardial dysfunction and death. The proposed sequential model of molecular, cellular and tissue mechanisms is provided in the flow diagram. The measured parameters indicating involvement of the proposed mechanisms are indicated in smaller italicized font. Kevin Bersell et al. Dis. Model. Mech. 2013;6:1459-1469 © 2013. Published by The Company of Biologists Ltd