IRF4 binds to and regulates histone acetylation of Il7r and Il2rb loci

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IRF4 binds to and regulates histone acetylation of Il7r and Il2rb loci. IRF4 binds to and regulates histone acetylation of Il7r and Il2rb loci. Purified control (Irf4 fl/fl) or IRF4-deficient CD8+ T cells were activated in vitro. (A) IRF4 binding site at the Il7r locus (left panel); IRF4 binding to the Il7r locus in control or IRF4-deficient CD8+ T cells was determined by ChIP (right panel). (B) IRF4 binding site at the Il2rb locus (left panel); IRF4 binding to the Il2rb locus in control or IRF4-deficient CD8+ T cells was determined by ChIP (right panel). (C) H3K27 acetylation in Il7r and Il2rb promoter regions of control or IRF4-deficient polyclonal CD8+ T cells was determined by ChIP. Data are representative of four independent experiments. Su Huang et al. ImmunoHorizons 2017;1:92-100 Copyright © 2017 The Authors