AhR activation reduces lung DC gene and surface expression of DC-SIGN.

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AhR activation reduces lung DC gene and surface expression of DC-SIGN. AhR activation reduces lung DC gene and surface expression of DC-SIGN. Mice were treated with vehicle control (V) or TCDD (T) 1 d prior to IAV infection, and all endpoints measured 3 d postinfection. (A) Cd209a gene expression in isolated lung DCs (CD11c+MHC II+ cells). (B) CD209a surface expression by percentage of total lung DCs from AhrWT and AhrKO. (C and D) Representative histograms depict the expression of CD209a on lung DCs from (C) AhrWT mice and (D) AhrKO mice. Numbers on the histograms indicate the MFI; fluorescence minus one (FMO) control (gray fill), V (blue line), and T (red line). (E) The percentage of cDC1s in the lung that were CD209a+. (F) The MFI of CD209 on cDC1s from the infected lung. (G) The percentage of lung cDC2s that were CD209a+. (H) The MFI of CD209a on cDC2s from the lung. (I) The percentage of lung DCs from infected Ahrfx/fx and AhrΔVav1 mice that express CD209a. (J) Histograms depict the expression of CD209a on lung DCs from Ahrfx/fx and AhrΔVav1 mice; numbers denote MFI in each group: FMO control (gray fill), V (Ahrfx/fx solid blue line, AhrΔVav1 light blue), and T (Ahrfx/fx solid red, AhrΔVav1 light red). Data are representative of three independent experiments. Group sizes within each experiment ranged from three to six mice per treatment group. The data represent the mean ± SEM for each group. *p < 0.05 by Student t test or one-way ANOVA. Anthony M. Franchini et al. ImmunoHorizons 2019;3:219-235 Copyright © 2019 The Authors