Adiponectin hypothesis for insulin resistance, the metabolic syndrome, and atherosclerosis Takashi Kadowaki, et al. J. Clin. Invest. 2006 116:1784-92.

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Presentation transcript:

Adiponectin hypothesis for insulin resistance, the metabolic syndrome, and atherosclerosis Takashi Kadowaki, et al. J. Clin. Invest. 2006 116:1784-92

Structure of adiponectin receptors Takashi Kadowaki, et al. J. Clin. Invest. 2006 116:1784-92

Signal transduction by adiponectin receptors Takashi Kadowaki, et al. J. Clin. Invest. 2006 116:1784-92

TZDs ameliorate insulin resistance and diabetes by both adiponectin-dependent and -independent pathways Takashi Kadowaki, et al. J. Clin. Invest. 2006 116:1784-92