BK virus nephritis after renal transplantation

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Presentation transcript:

BK virus nephritis after renal transplantation S. Hariharan Kidney International Volume 69, Issue 4, Pages 655-662 (February 2006) DOI: 10.1038/sj.ki.5000040 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Renal histological findings of interstitial infiltrates and viral cytopathic effects in a case with BKVN. Kidney International 2006 69, 655-662DOI: (10.1038/sj.ki.5000040) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 (a) Evolution of renal function using 100/serum creatinine, illustrating progressive renal failure in a case with BKVN. (b) Evolution of renal function using 100/serum creatinine, illustrating stabilization of renal function in a case with BKVN. Kidney International 2006 69, 655-662DOI: (10.1038/sj.ki.5000040) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 3 Lower actuarial graft survival rates in patients with BKVN – results from the Medical College of Wisconsin 1996–2004. Kidney International 2006 69, 655-662DOI: (10.1038/sj.ki.5000040) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 4 Potential pathogenetic mechanisms involved in the occurrence of BKVN from BK viremia. These include sources of BKV infection, molecular viral type, renal tropism, host immunity, and renal transplant ischemic injury prior to engraftment, alloimmune activation, immunosuppression type, and defect in CD40 ligand. Kidney International 2006 69, 655-662DOI: (10.1038/sj.ki.5000040) Copyright © 2006 International Society of Nephrology Terms and Conditions