Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe.

Slides:

Advertisements

Similar presentations

Wei Wu, PhD, Eugene Bleecker, MD, Wendy Moore, MD, William W

Advertisements

Test for Respiratory and Asthma Control in Kids (TRACK): Clinically meaningful changes in score Robert S. Zeiger, MD, PhD, Michael Mellon, MD, Bradley.

Jonathan Malka, MD, David T

Risk of an asthma exacerbation after bariatric surgery in adults

Pharmacologic rationale for treating allergic and nonallergic rhinitis

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Advances in pediatric asthma in 2011: Moving forward

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study John M. Brehm, MD, MPH, Brooke Schuemann, BS,

Applying epidemiologic concepts of primary, secondary, and tertiary prevention to the elimination of racial disparities in asthma Christine L.M. Joseph,

Is 9 more than 2 also in allergic airway inflammation?

Children with allergic and nonallergic rhinitis have a similar risk of asthma Bo Lund Krogsgaard Chawes, MD, Klaus Bønnelykke, MD, PhD, Eskil Kreiner-Møller,

NAEPP Expert Panel Report

Advancing asthma care: The glass is only half full!

Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence L. Keoki Williams, MD, MPH, Edward L. Peterson,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Impact of Asthma Exacerbations and Asthma Triggers on Asthma-related Quality of Life in Patients with Severe or Difficult-to-Treat Asthma Allan T. Luskin,

Test for Respiratory and Asthma Control in Kids (TRACK): A caregiver-completed questionnaire for preschool-aged children Kevin R. Murphy, MD, Robert.

The Childhood Asthma Control Test∗: Retrospective determination and clinical validation of a cut point to identify children with very poorly controlled.

Asthma Exacerbations and Triggers in Children in TENOR: Impact on Quality of Life Bradley E. Chipps, MD, Tmirah Haselkorn, PhD, Karin Rosén, MD, PhD,

The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: A systematic review and meta-analysis of randomized controlled trials

Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis George Philip, MD, Janet van Adelsberg, MD, Thomas Loeys, PhD, Nancy.

Demographic and clinical characteristics of children and adolescents with severe or difficult-to-treat asthma Bradley E. Chipps, MD, Stanley J. Szefler,

Physician needs in health informatics: Just ask the docs

Treatment of chronic autoimmune urticaria with omalizumab

Omalizumab Effectiveness by Biomarker Status in Patients with Asthma: Evidence From PROSPERO, A Prospective Real-World Study Thomas B. Casale, MD, Allan.

Peter M. Wolfgram, MD, David B. Allen, MD

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

Consistently very poorly controlled asthma is associated with greater activity and school impairment in children with severe or difficult-to-treat asthma

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

High eosinophil count: A potential biomarker for assessing successful omalizumab treatment effects William Busse, MD, Sheldon Spector, MD, Karin Rosén,

A review of the current guidelines for allergic rhinitis and asthma

Gene Colice, MD, Richard J

Acute asthma intervention: Insights from the STAY study

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study Bradley E.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Wendy C. Moore, MD, Michael D. Evans, MS, Eugene R

Justin R. Chen, MD, Brett L. Buchmiller, MD, David A. Khan, MD

Nicola A. Hanania, MB BS, MS, Bradley E. Chipps, MD, Noelle M

Michael Schatz, MD, MS, Robert S

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

Lara J. Akinbami, MD, Jeanne E. Moorman, MS, Alan E

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

What is an “eosinophilic phenotype” of asthma?

Lyndsey A. Darrow, PhD, Jeremy Hess, MD, Christine A

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Diagnosis and management of early asthma in preschool-aged children

Geographic variability in childhood asthma prevalence in Chicago

Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program Christy Gamble, DrPHc, MPH, Evelyn Talbott,

News Beyond Our Pages Journal of Allergy and Clinical Immunology

The Editors' Choice Journal of Allergy and Clinical Immunology

The impact of a history of asthma on long-term outcomes of people with newly diagnosed chronic obstructive pulmonary disease: A population study Tetyana.

Risk of oral food challenges

National prevalence and risk factors for food allergy and relationship to asthma: Results from the National Health and Nutrition Examination Survey

Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A

Asthma progression: Can we and should we measure it?

The Editors' Choice Journal of Allergy and Clinical Immunology

Severity assessment in asthma: An evolving concept

Managing asthma exacerbations in the emergency department: Summary of the National Asthma Education and Prevention Program Expert Panel Report 3 guidelines.

Macrolide antibiotics and asthma treatment

Wei Wu, PhD, Eugene Bleecker, MD, Wendy Moore, MD, William W

Advances in pediatric asthma in 2007

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Modeling asthma exacerbations through lung function in children

Presentation transcript:

Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study Tmirah Haselkorn, PhD, James E. Fish, MD, Robert S. Zeiger, MD, PhD, Stanley J. Szefler, MD, Dave P. Miller, Bradley E. Chipps, MD, F. Estelle R. Simons, MD, Scott T. Weiss, MD, MS, Sally E. Wenzel, MD, Larry Borish, MD, Eugene R. Bleecker, MD Journal of Allergy and Clinical Immunology Volume 124, Issue 5, Pages 895-902.e4 (November 2009) DOI: 10.1016/j.jaci.2009.07.035 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Study population. Two hundred sixty-seven of 1074 patients whose pattern of asthma control was VPC-VPC-(N)WC or VPC-N(WC)-VPC were excluded. ∗Asthma control assessments at baseline, month 12, and month 24. Journal of Allergy and Clinical Immunology 2009 124, 895-902.e4DOI: (10.1016/j.jaci.2009.07.035) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Risk of asthma exacerbations at the month 30 visit associated with consistently VPC asthma as defined by impairment domain of the NHLBI guidelines. Final adjusted models for hospitalization and ED visits include prior hospitalizations or ED visits, number of long-term controllers, body mass index, allergic triggers, nonallergic triggers, percent predicted forced vital capacity, race/ethnicity, and age. Final adjusted models for corticosteroid bursts include prior corticosteroid burst, chronic obstructive pulmonary disease, nonallergic triggers, percent predicted FEV1/forced vital capacity ratio, race/ethnicity, and age. Journal of Allergy and Clinical Immunology 2009 124, 895-902.e4DOI: (10.1016/j.jaci.2009.07.035) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Demographic and clinical factors predictive of consistently VPC asthma as defined by the impairment domain of the NHLBI guidelines. ∗Allergic triggers considered were pollen, animal dander, dust, and mold. ∗∗Predictive factors that were statistically significantly associated with consistently poorly controlled asthma are shown. Journal of Allergy and Clinical Immunology 2009 124, 895-902.e4DOI: (10.1016/j.jaci.2009.07.035) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions