Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence Devasmitha Venkataraman, MD, MRCPCH, MSc, Nelís Soto-Ramírez,

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Presentation transcript:

Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence Devasmitha Venkataraman, MD, MRCPCH, MSc, Nelís Soto-Ramírez, MPH, MD, Ramesh J. Kurukulaaratchy, DM, FRCP, John W. Holloway, PhD, Wilfried Karmaus, MD, Drmed, MPH, Susan L. Ewart, PhD, S. Hasan Arshad, FRCP, DM, Mich Erlewyn-Lajeunesse, FRCPCH, DM Journal of Allergy and Clinical Immunology Volume 134, Issue 4, Pages 876-882.e4 (October 2014) DOI: 10.1016/j.jaci.2014.07.033 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Odds of having FA in children with FLG-LOF mutations at 1, 2, 4, 10, and 18 years of age. A significant association was seen between FLG-LOF mutation and FA at ages 10 and 18 years (logistic regression). Journal of Allergy and Clinical Immunology 2014 134, 876-882.e4DOI: (10.1016/j.jaci.2014.07.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Analytic path model exploring the total effects of FLG-LOF mutation and eczema at ages 1 and 2 years and 4 years on FA and FAS at 4, 10, and 18 years of age. The path coefficient (total effects) represents the ORs. Goodness of fit adjusted for degrees of freedom = 0.99; comparative fit index = 0.99; root mean square error of approximation = ≤0.06; deviation between covariance structure and empiric covariance = χ2/df ≤ 2; P < .05. Only significant direct paths are shown. The relationship between FLG-LOF mutations and FAS was not explored at 1 and 2 years of age because only symptomatic children underwent SPTs and FAS were data not available in the whole cohort. Journal of Allergy and Clinical Immunology 2014 134, 876-882.e4DOI: (10.1016/j.jaci.2014.07.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Analytic path model exploring the direct effects of FLG-LOF mutation and eczema at ages 1 and 2 years and 4 years on FA and FAS at 4, 10, and 18 years of age. The path coefficient (direct effects) represents the ORs. Goodness of fit adjusted for df = 0.99; comparative fit index = 0.99; root mean square error of approximation = ≤0.06; deviation between covariance structure and the empiric covariance = χ2/df ≤ 2; P < .05. Only significant direct paths are shown. The relationship between FLG-LOF mutations and FAS was not explored at 1 and 2 years of age because only symptomatic children underwent SPTs and FAS data were not available in the whole cohort. Journal of Allergy and Clinical Immunology 2014 134, 876-882.e4DOI: (10.1016/j.jaci.2014.07.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Participation data/availability of information at ages 1, 2, 4, 10, and 18 years in the IOW birth cohort study. Journal of Allergy and Clinical Immunology 2014 134, 876-882.e4DOI: (10.1016/j.jaci.2014.07.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions