A New Locus for Autosomal Recessive Hypercholesterolemia Maps to Human Chromosome 15q25-q26 Milco Ciccarese, Adolfo Pacifico, Giancarlo Tonolo, Paolo.

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A New Locus for Autosomal Recessive Hypercholesterolemia Maps to Human Chromosome 15q25-q26 Milco Ciccarese, Adolfo Pacifico, Giancarlo Tonolo, Paolo Pintus, Andrej Nikoshkov, Giovanni Zuliani, Renato Fellin, Holger Luthman, Mario Maioli The American Journal of Human Genetics Volume 66, Issue 2, Pages 453-460 (February 2000) DOI: 10.1086/302753 Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 1 Structure of the five Sardinian pedigrees with hypercholesterolemia. Circles denote females; squares, males; blackened symbols, affected individuals. Double lines indicate consanguineous matings. Numbers below each symbol indicate age at the time of this study or age at death; numbers inside symbols indicate the number of siblings with an identical phenotype. Stars above symbols denote individuals included in the linkage analysis. The American Journal of Human Genetics 2000 66, 453-460DOI: (10.1086/302753) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 2 Suggested haplotypes of chromosome 15q24-15qter in families with ARH. The common region shared in affected individuals within each family is boxed. Displayed haplotypes were calculated by use of the GENEHUNTER program. The American Journal of Human Genetics 2000 66, 453-460DOI: (10.1086/302753) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 3 Multipoint linkage analysis of ARH, displaying chromosome 15 results. Markers are indicated below the X-axis. The ARP1 gene is located at 15q25-15q26. The American Journal of Human Genetics 2000 66, 453-460DOI: (10.1086/302753) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 4 Multipoint-linkage-analysis data for all chromosomes except the sex chromosomes. LOD scores >−2 are hidden and indicate that the chromosome region is excluded for linkage. Chromosome X was excluded by single-point analysis, with use of LINKAGE software, version 5.1. The American Journal of Human Genetics 2000 66, 453-460DOI: (10.1086/302753) Copyright © 2000 The American Society of Human Genetics Terms and Conditions