Michael L. Marin, MD, Ronald E. Gordon, PhD, Frank J

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Distribution of c-myc oncoprotein in healthy and atherosclerotic human carotid arteries Michael L. Marin, MD, Ronald E. Gordon, PhD, Frank J. Veith, MD, Natalie Tulchin, PhD, Thomas F. Panetta, MD Journal of Vascular Surgery Volume 18, Issue 2, Pages 170-177 (August 1993) DOI: 10.1016/0741-5214(93)90596-E Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Light micrograph of serial sections from healthy human carotid artery. A, Media is composed of uniformly structured SMCs with interposed elastin and collagen fibers. (Hemotoxylin-eosin stain; original magnification × 200.) B, Immunohistochemical staining for α-SMC actin. Immunostaining of cytoplasm is uniformly seen in medial SMCs (arrowheads). (Papanicolaou's stain; original magnification × 200.) C, Immunohistochemical staining for c-myc oncoprotein. Occasional isolated cells throughout media demonstrate positive reaction product in nucleus (arrows). (Papanicolaou's stain; original magnification × 100.) D, Immunohistochemical controls with preimmune serum for c-myc show no nuclear staining. (Papanicolaou's stain; original magnification × 100.) Journal of Vascular Surgery 1993 18, 170-177DOI: (10.1016/0741-5214(93)90596-E) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Light micrograph of serial sections through human carotid plaque from endarterectomy specimen. A, Fibrocellular tissue (F) overlies aggregates of SMCs (s). L, Lumen. (Hematoxylin-eosin stain; original magnification × 200.) B, Serial section of A exposed to anti-α SMC actin antibody demonstrates uniform cytoplasmic immunostaining of cells. (Papanicolaou's stain; original magnification × 200.) c, Immunostaining for product of c-myc protooncogene shows nuclear staining in majority of SMCs from corresponding regions in C. Inset, High-powered magnification of nuclei from plaque cells demonstrates staining intensity of 2 + (arrow). (Papanicolaou's stain; original magnification of A, × 200; inset, × 1000.) D, Immunohistochemical controls with preimmune serum for c-myc show no nuclear staining. (Papanicolaou's stain; original magnification × 100.) Journal of Vascular Surgery 1993 18, 170-177DOI: (10.1016/0741-5214(93)90596-E) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions