Loss of chw-1 but not crp-1 attenuates the defects in the VD/DD motor neurons driven by activated SAX-3. Loss of chw-1 but not crp-1 attenuates the defects.

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Loss of chw-1 but not crp-1 attenuates the defects in the VD/DD motor neurons driven by activated SAX-3. Loss of chw-1 but not crp-1 attenuates the defects in the VD/DD motor neurons driven by activated SAX-3. A) A representation of the MYR-SAX-3 construct. B) A micrograph of the VD/DD neurons of a WT adult animal (top panel), and the VD/DD neurons of an adult animal expressing MYR-SAX-3 (bottom panel). C) Quantitation of VD/DD defects. unc-25::myr-sax-3 is the activated SAX-3 receptor driven by the unc-25 promoter, which drives expression in the VD/DD motor neurons. The Y-axis denotes the genotype and the X-axis represents the percentage of ectopic lamellipodia formation. The number of axons scored was greater than 100. *P < 0.0004 as determined by Fisher Exact Analysis. The error bars represent the standard proportion of the mean. The scale bar represents 20 μm. Jamie K. Alan et al. G3 2018;8:1885-1895 ©2018 by Genetics Society of America